Table 2

Clinical and pathological data, histological diagnoses, histology findings and immunohistochemical expression in the benign adipose tumours group

Case no.	Sex/age	Localisation/size (cm)	Diagnoses	Histology	IHC MDM2/CDK4	Pattern of staining	Observations
3	M/51	Cervical/4	PL-LP	Numerous floret cells, fibrillary collagen	−/+	4/2	CD34+
6	F/24	Mediastinum/8	TLP	Infiltrative adipocytes	−/−	4/4
11	F/72	Cervical/3	SC-LP	Spindle cells, fibrillary collagen	−/−	4/4	CD34+
12	M/33	Dorsum/15	NC-LP	Esteatonecrosis, atypical nuclei, reactive myofibroblasts, lockern	−/−	4/4	No MDM2 amplification by FISH*
23	M/44	Dorsum/3	NC-LP	Esteatonecrosis, atypical nuclei, reactive myofibroblasts	+/−	2/4
24	M/49	Cervical/15	NC-LP	Myxoid stroma	−/−	4/4
25	F/19	Knee/14	FBLP	Fibrous sclerotic stroma	+/−	2/4	Some CD34+ cells, possible Gardner type fibroma
26	F/32	Gluteus/15	NC-LP	Adipocyte size variation, atypical/large nuclei	−/−	4/4
42	M/28	Forearm/2	NFBLP	Infiltrative adipocytes	−/−	4/4
47	F/41	Inguinal/13	NC-LP	Adipocyte size variation, atypical/large nuclei	−/−	4/4
49	F/45	Cervical/3	SC-LP	Spindle cells, fibrillary collagen	+/+	2/2	CD34+
55	F/37	Kidney/12	AMLP	Perirrenal fat infiltration	+/−	2/4
65	M/35	Thigh/38	HIB	Hibernoma cells, dense fibrous stroma	−/−	4/4	No CPM amplification by FISH*
76	M/37	Thigh/25	IM-LP	Rare hibernomatous cells, infiltrative pattern	+/−	2/4
110	F/62	Malar/NI	SC-LP	Spindle cells, fibrillary collagen	+/−	1/4	CD34+
113	F/57	Hand/7	NC-LP	Myxoid stroma	+/−	2/4
128	F/47	Arm/4	PL-LP	Hyperchromatic cells, fibrillary collagen	−/−	4/4	CD34+, no CPM amplification by FISH*

Staining pattern: 1, diffuse positivity (>30% of cells were immunoreactive); 2, moderate positivity (10–29% of cells were immunoreactive); 3, focal positivity (<10% of cells were immunoreactive); 4, negative (no cell was immunoreactive).
*Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA.
M, male; F, female; PL-LP, pleomorphic lipoma; TLP, timolipoma; SC-LP, spindle cell lipoma; NC-LP, non-conventional lipoma; FBLP, fibrolipoma; NFBLP, neural fibrolipoma; AMLP, angiomyolipoma; HIB, hibernoma; IM-LP, intramuscular lipoma.