Table 4

MDM2 and CDK4 immunohistochemistry results in all tumour groups

Groups/diagnoses (T)MDM2CDK4MDM2 and CDK4
N/T (%)N/T (%)N/T (%)
WDLPS (19)19/19 (100)13/19 (68.4)13/19 (68.4)
DDLPS (10)9/10 (90)7/10 (70)7/10 (70)
WDLPS/DDLPS (29)28/29 (96.5)20/29 (68.9)20/29 (68.9)
Other mesenquimal tumours (83)29/83 (34.9)3/83 (3.6)2/83 (2.4)
HG-UPS* (26)10/26 (38.4)1/26 (3.8)0/26 (0)
MXFBS* (5)4/5 (80)1/5 (20)1/5 (20)
FBS* (3)1/3 (33.3)0/3 (0)0/3 (0)
LMS* (8)2/8 (25)0/8 (0)0/8 (0)
RBMS* (2)0/2 (0)0/2 (0)0/2 (0)
MPNST* (7)3/7 (42.8)0/7 (0)0/7 (0)
SS (8)2/8 (25)0/8 (0)0/8 (0)
EPITS (3)1/3 (33.3)0/3 (0)0/3 (0)
KS (2)0/2 (0)0/2 (0)0/2 (0)
GIST (4)2/4 (50)0/4 (0)0/4 (0)
OTS* (3)0/3 (0)0/3 (0)0/3 (0)
DFSP (1)1/1 (100)0/1 (0)0/1 (0)
MRLPS* (4)1/4 (25)0/4 (0)0/4 (0)
CCS (1)0/1 (0)0/1 (0)0/1 (0)
PLPS* (2)1/2 (50)1/2 (50)1/2 (50)
LGFMS (1)1/1 (100)0/1 (0)0/1 (0)
AGS* (1)0/1 (0)0/1 (0)0/1 (0)
EPITH (1)0/1 (0)0/1 (0)0/1 (0)
SFT (1)0/1 (0)0/1 (0)0/1 (0)
Benign adipocytic tumours (17)7/17 (41.1)2/17 (11.7)1/17 (5.8)
NC-LP (6)2/6 (33.3)0/6 (0)0/6 (0)
CF-LP (3)2/3 (66.6)1/3 (33.3)1/3 (33.3)
PL-LP (2)0/2 (0)1/2 (50)0/2 (0)
HIB (1)0/1 (0)0/1 (0)0/1 (0)
FBLP (1)1/1 (100)0/1 (0)0/1 (0)
IM-LP (1)1/1 (100)0/1 (0)0/1 (0)
AMLP (1)1/1 (100)0/1 (0)0/1 (0)
NFBLP (1)0/1 (0)0/1 (0)0/1 (0)
TLP (1)0/1 (0)0/1 (0)0/1 (0)
  • *Neoplasia can simulate DDLPS.

  • T, total number of cases; N, number of cases; WDLPS, well differentiated liposarcoma; DDLPS, dedifferentiated liposarcoma; PL-LP, pleomorphic lipoma; TLP, timolipoma; SC-LP, spindle cell lipoma; NC-LP, non-conventional lipoma; FBLP, fibrolipoma; NFBLP, neural fibrolipoma; AMLP, angiomyolipoma; HIB, hibernoma; IM-LP, intramuscular lipoma; FBS, fibrosarcoma; GIST, gastrointestinal stromal tumour; MPNST, malignant peripheral nerve sheath tumour; MXFBS, myxofibrosarcoma; HG-UPS, high grade undifferentiated pleomorphic sarcoma; MRLPS, myxoid round cell liposarcoma; LMS, leiomyosarcoma; SS, synovial sarcoma; PLPS, pleomorphic liposarcoma; OTS, osteosarcoma; DFSP, dermatofibrosarcoma protuberans; AGS, angiosarcoma; SFT, solitary fibrous tumours; LGFMS, low grade fibromyxoid sarcoma; EPITS, epithelioid sarcoma; RBMS, rhabdomyosarcoma; EPITH, epithelioid hemangioendothelioma; KS, Kaposi sarcoma; CCS, clear cell sarcoma.