Statistical analyses of immunohistochemistry results for MDM2 and CDK4 in the diagnostic groups
| Protein | Comparisons | ||
| WDLPS/DDLPS vs BAT/OMT (n = 129) | WDLPS vs BAT (n = 36) | DDLPS vs OMT (n = 93) | |
| MDM2 | |||
| Sensitivity | 96.5% | 100% | 90% |
| Specificity | 64% | 58.8% | 65% |
| PPV | 43.8% | 73.1% | 23.7% |
| NPV | 98.5% | 100% | 98.2% |
| Accuracy | 71% | 81% | 68% |
| Youden’s J | 0.6 | 0.58 | 0.55 |
| κ (p-value) | 0.42 (<0.001) | 0.6 (<0.001) | 0.24 (<0.001) |
| CDK4 | |||
| Sensitivity | 68.9% | 68.4% | 70% |
| Specificity | 95% | 88.2% | 96.3% |
| VPP | 80% | 86.7% | 70% |
| VPN | 91.3% | 71.4% | 96.4% |
| Accuracy | 89% | 78% | 94% |
| Youden’s J | 0.64 | 0.56 | 0.66 |
| κ (p-value) | 0.67 (<0.001) | 0.56 (0.001) | 0.66 (<0.001) |
| MDM2 and CDK4 | |||
| Sensitivity | 68.9% | 68.4% | 70% |
| Specificity | 97% | 94.1% | 97.5% |
| PPV | 87% | 92.9% | 77.8% |
| NPV | 91.5% | 72.7% | 96.4% |
| Accuracy | 91% | 81% | 95% |
| Youden’s J | 0.66 | 0.62 | 0.67 |
| κ (p-value) | 0.71 (<0.001) | 0.61 (<0.001) | 0.7 (<0.001) |
PPV, positive predictive value; NPV, negative predictive value; WDLPS, well differentiated liposarcoma; DDLPS, dedifferentiated liposarcoma; BAT, benign adipose tumours; OMT, other mesenquimal tumours.