Table 2 Expression of pro-apoptotic and anti-apoptotic molecules, and levels of significance in ET, PMF and control samples
MoleculeFunctionET*PMF*Control*p Value
Bcl-XLAnti-apoptotic50.5 (24.19)35 (28.06)<5 (2.88)0.036
BaxPro-apoptotic30.5 (19.87)55 (18.89)17.5 (12.05)0.001
BadPro-apoptotic41 (24.18)52 (25.20)30 (15.28)0.068
hTERTAnti-apoptotic32 (15.52)46 (17.77)0.022
Caspase-3Effector11 (15.41)29.5 (23.51)13 (7.32)0.006
  • *Values are percentages of positive MKCs, mean (SD).

  • ET, essential thrombocythaemia; hTERT, human telomerase reverse transcriptase; MKC, megakaryocyte; PMF, primary myelofibrosis.