Table 4 Roenigk classification system51

Roenigk grade	Fatty change	Nuclear pleomorphism	Necroinflammatory damage	Fibrosis
I	Mild or none	Mild or none	Mild or none	None
II	Moderate or severe	Moderate or severe	Moderate or severe portal inflammation	None
IIIa	With or without	With or without	With or without	Mild
IIIb	With or without	With or without	With or without	Moderate or severe
IV	With or without	With or without	With or without	Cirrhosis

A score of IIIb or IV is an indication to discontinue the drug. Early detection and discontinuation of the drug is associated with a favourable outcome.