Enzyme | ||||||
DPD | OPRT | TS | TK | TP | dUTPase | |
Patients with metastasis (%) | 17 (6/35) | 83 (29/35) | 20 (7/35) | 26 (9/35) | 9 (3/35) | 54 (19/35) |
Patients with no metastasis (%) | 45 (9/20) | 60 (12/20) | 5 (1/20) | 0 (0/20) | 0 (0/20) | 15 (3/20) |
Fisher’s exact test, p value | 0.033 | 0.106 | 0.234 | 0.019 | 0.293 | 0.005 |
*Fisher’s exact test was applied to 2×2 tables defined by marker status (+/−) and metastasis status to test the null hypothesis that the odds ratio was unity.
DPD, dihydropyrimidine dehydrogenase; dUTPase, deoxyuridine triphosphatase; OPRT, orotate phosphoribosyl transferase; TK, thymidine kinase; TP, thymidine phosphorylase; TS, thymidylate synthase.