Table 3 The expression of 5-fluorouracil-related enzymes between primary tumours and metastatic tumours
EnzymePrimary siteMetastasis siteAltered expression*
NegativePositiveTotal
DPDNegative27229Increased: 2/29 = 6.9%
Positive516 (17%)Decreased: 5/6 = 83.3%
Total323 (9%)35Altered: 7/35 = 20.0%
OPRTNegative066Increased: 6/6 = 100%
Positive62329 (83%)Decreased: 6/29 = 20.7%
Total629 (83%)35Altered: 12/35 = 34.3%
TSNegative19928Increased: 9/28 = 32.1%
Positive527 (20%)Decreased: 5/7 = 71.4%
Total2411 (31%)35Altered: 14/35 = 40.0%
TKNegative23326Increased: 3/26 = 11.5%
Positive639 (26%)Decreased: 6/9 = 66.7%
Total296 (17%)35Altered: 9/35 = 25.7%
TPNegative30232Increased: 2/32 = 6.3%
Positive303 (9%)Decreased: 3/3 = 100%
Total332 (6%)35Altered: 5/35 = 14.3%
dUTPaseNegative8816Increased: 8/16 = 50.0%
Positive71219 (54%)Decreased: 7/19 = 36.8%
Total1520 (57%)35Altered: 15/35 = 42.9%
  • *Altered expression is indicated by determination of each enzymes expression in the primary tumour versus to the metastatic tumour. The rates of cases with positive or negative expression in the metastasis among cases with negative or positive expression in the primary tumour are indicated as increased or decreased. The rates of altered expression in the metastasis relative to that in the primary tumour are given in the row labelled as altered.

  • DPD, dihydropyrimidine dehydrogenase; dUTPase, deoxyuridine triphosphatase; OPRT, orotate phosphoribosyl transferase; TK, thymidine kinase; TP, thymidine phosphorylase; TS, thymidylate synthase.