Table 1

Kappa values for agreement between pairs of pathologists before and after additional interpretation of p16^INK4a stained sections

All histoloqical categories	H&E-based diagnosis	95% CI	p16-supported diagnosis	95% CI
Kappa values (weighted)
PA1 versus PA 2	0.44	0.19 to 0.64	0.82	0.52 to 0.92
PA1 versus PA 3	0.66	0.47 to 0.79	0.80	0.67 to 0.88
PA 2 versus PA 3	0.53	0.29 to 0.70	0.79	0.54 to 0.91
Group (mean) kappa	0.54	0.38 to 0.69	0.80	0.66 to 0.89

Kappa values (unweighted)
Two categories (≤CIN1–CIN2/3)
PA 1 versus PA 2	0.32	0.04 to 0.55	0.80	0.66 to 0.88
PA 1 versus PA 3	0.64	0.44 to 0.78	0.67	0.48 to 0.80
PA 2 versus PA 3	0.37	0.11 to 0.58	0.80	0.67 to 0.88
Group (mean) kappa	0.44	0.27 to 0.60	0.76	0.64 to 0.84