Table 1

Presentation and investigations

PtAgePrevious therapy for idiopathic thrombocytopenic purpuraIgs and lymphocytes pre-rituximabHistory of infections pre-rituximabDate (and cycles) of rituximabIgs and lymphocytes†History of infections post-rituximab
143
  • Steroids

  • Splenectomy Cyclophosphamide

  • Alpha interferon

  • Ciclosporin A

  • Azathioprine

  • Intravenous Ig

  • Danazol

  • Tranexamic acid

  • Igs*

  • IgG

  • IgA

  • IgM

  • Nov 91

  • 12.41

  • 0.42

  • 1.10

  • Pneumococcal meningitis (1989 and 1991)

  • Ear infections

  • Mar 06 (4)

  • Igs*

  • IgG

  • IgA

  • IgM

  • Jun 07

  • 2.24

  • <0.1

  • 0.18

  1. Recurrent lower respiratory tract infections and sinusitis (since Apr 06)

  • Lymph

  • Not available

  • Lymph

  • CD3

  • CD4

  • CD8

  • CD19

  • Jun 07

  • 4020

  • 2160

  • 2166

  • 121

2NA
  • Steroids

  • Splenectomy

  • Ciclosporin A

  • Azathioprine

  • IV Ig

  • Igs*

  • IgG

  • IgA

  • IgM

  • Dec 91

  • 7.84

  • 0.50

  • 0.80

  • Jun 03

  • 4.7

  • <0.14

  • 2.24

  • Nil significant

  • Aug 03 (4)

  • Jun 06 (4)

  • Igs*

  • IgG

  • IgA

  • IgM

  • Jul 07

  • 1.5

  • <0.05

  • 0.04

  1. Pneumonia requiring intravenous antibiotics (Dec 06)

  2. Mediastinal mass?TB (Jan 07)

  3. Otitis media (Jul 07)

  4. Hepatic encephalopathy, sepsis, adenovirus enteritis (Oct 07)

  • Lymph

  • CD3

  • CD4

  • CD8

  • CD19

  • May 93

  • 1087

  • 580

  • 435

  • 290

  • Lymph

  • CD3

  • CD4

  • CD8

  • CD19

  • Aug 07

  • 1267

  • 699

  • 547

  • 1

  • * Normal adult ranges for immunoglobulins: IgG: 6–16 g/l; IgA 0.8–2.8 g/l; IgM 0.5–2 g/l.

  • At presentation to immunology clinic.

  • Lymphocyte subset analysis (×106/l).