Table 1

Predicted time to reach steady state in patients without impaired clearance mechanisms

Drugtss (days)
Carbamazepine7*
Clonazepam6
Ethosuximide10
Gabapentin2
Lamotrigine5†
Methylphenobarbitone
Phenobarbitone20
Phenytoin5
Primidone
Tsagabine1–1.5
Topiramate4–6
Valproate2–3
Vigabatrin2
  • * This value is calculated from the half-life. In practice the value may be appreciably shorter because of autoinduction of metabolism or longer with new therapy as autoinduction progresses over 2–3 weeks.

  • Longer in persons co-medicated with valproate, shorter in those co-medicated with microsomal enzyme-inducing antiepileptic drugs, for example phenytoin.