Drug | tss (days) |
Carbamazepine | 7* |
Clonazepam | 6 |
Ethosuximide | 10 |
Gabapentin | 2 |
Lamotrigine | 5† |
Methylphenobarbitone | |
Phenobarbitone | 20 |
Phenytoin | 5 |
Primidone | |
Tsagabine | 1–1.5 |
Topiramate | 4–6 |
Valproate | 2–3 |
Vigabatrin | 2 |
↵* This value is calculated from the half-life. In practice the value may be appreciably shorter because of autoinduction of metabolism or longer with new therapy as autoinduction progresses over 2–3 weeks.
↵† Longer in persons co-medicated with valproate, shorter in those co-medicated with microsomal enzyme-inducing antiepileptic drugs, for example phenytoin.