Table 3

Fold-difference values for 88 genes in each of eight subtypes (A–H) in 114 subtyped patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Genes without values for the subtypes are those for which there was missing data for one or more subtypes. Bold type indicates genes targeted by existing drugs and those CFS/ME subtypes in which fold-difference values of 1.5 were found

Gene symbol	Genbank accession	CFS/ME subtype
Gene symbol	Genbank accession	A	B	C	D	E	F	G	H
ABCD4	NM_020323	1.40	0.60	0.81	4.40	10.61	7.02	1.32	0.93
ACTR3	NM_005721	10.17	8.03	4.34	25.73	13.95	6.75	27.57	5.35
AKAP10	NM_007202	3.83	3.25	1.68	8.39	5.59	6.61	4.89	1.64
ANAPC11	NM_016476	2.53	2.66	4.34	3.74	1.59	4.16	2.27
ANAPC5	NM_016237	1.13	1.26	4.49	1.92	0.78	0.00	2.96	2.95
APP	NM_201413	0.63	1.73	1.42	0.56	4.64	0.84	0.84	2.58
ARL4C	NM_005737	6.62	7.40	2.72	5.85	7.82	8.76	6.68	2.81
ARPC5	NM_005717	2.55	0.81	1.53	5.65	4.87	3.41	4.92	3.01
ARSD	NM_001669	0.64	1.17	1.51	4.60	2.62	0.26	0.12	2.19
ATP6V1C1	NM_001695	1.99	3.80	3.38	2.43	2.06	0.72	3.63	4.55
BCOR	NM_017745	1.42	2.22	1.78	2.30	6.52	1.13	2.65	2.57
BMP2K	NM_198892	8.96	4.83	2.62	16.42	7.76	3.78	11.57	2.06
BRMS1	NM_015399	1.31	4.38	2.44	1.53	4.62	7.06	2.57	3.83
CD2BP2	NM_006110	3.89	1.37	2.21	6.77	4.52	1.33	5.99	3.55
CD47	NM_198793	2.60	6.90	3.37	3.66	4.06	0.95	4.13	2.75
CEP350	NM_014810	3.50	4.47	3.66	5.30	4.50	1.22	5.04	2.04
CITED2	NM_006079	6.43	6.84	1.97	4.95	6.02	4.40	5.50	3.42
CMTM6	NM_017801	3.10	3.70	0.69	10.04	7.81	4.77	1.71	0.73
CREBBP	NM_004380	7.11	1.62	1.09	13.34	5.46	2.61	8.99	3.62
CRK	NM_016823	1.83	5.57	1.26	2.82	4.89	1.03	2.25	2.02
CTBP1	NM_001328	4.95	4.98	1.05	8.62	15.44	3.43	2.42	2.73
CXCR4	NM_003467	13.47	2.18	2.03	28.10	17.57	1.48	10.29	3.57
EBI2	NM_004951	5.67	1.41	2.31	14.93	5.99	0.76	0.42	4.47
EGR1	NM_001955	0.49	2.85	2.42	0.30	0.27	1.00	1.98	2.96
EGR3	NM_004421	0.95	1.33	0.46		5.36		1.39	0.98
EIF2B4	NM_172195	1.44	0.52	1.33	6.00	3.48	0.15	1.69	2.08
EIF3S10	NM_003750	1.43	4.42	2.10	1.72	1.48	1.25	2.83	6.16
EIF4G1	NM_198241	1.13	3.47	3.52	0.99	1.39	2.30	4.53	14.27
EIF4G3	NM_003760	2.40	0.79	0.77	5.46	27.42	1.09	3.62	1.55
ETS1	NM_005238	35.12	4.63	4.16	52.65	30.36	17.54	24.17	6.91
FAM126B	NM_173822	2.04	0.63	0.91	10.18	5.51	2.59	1.31	0.71
FNTA	NM_002027	1.39	5.72	2.99	3.88	5.07	2.14	7.88	4.06
GABARAPL1	NM_031412	6.08	6.42	3.37	2.93	8.49	2.58	6.23	5.74
GABPA	NM_002031	11.96	8.56	21.93	3.10	5.71	25.83	13.38	55.99
GCN1L1	NM_006836	0.80	1.40	1.91	0.44	5.85	1.13	1.59	2.38
GLTSCR2	NM_015710	3.68	2.46	0.53	4.94	6.98	4.07	10.28	0.80
GNAS	NM_080425	1.72	1.13	1.81	3.62	3.18	1.96	3.47	2.20
GSN	NM_198252	1.73	1.27	1.69	3.82	2.36	1.64	3.51	5.81
GTF2A2	NM_004492	0.71	0.53	1.21	0.53	2.19	0.48	1.65	0.87
HIF1A	NM_001530	2.04	0.87	0.82	5.14	4.22	1.66	4.65	1.35
IFNAR1	NM_000629	1.86	0.17	0.79	3.55	5.53	1.41	7.17	0.91
IL10RA	NM_001558	1.12	2.68	0.74			2.31	1.01	1.76
IL6R	NM_000565	2.19		2.47			2.78	2.67
IL6ST	NM_002184	2.61	1.49	4.81	3.14	3.07	2.67	3.76
IL7R	NM_002185	1.43	0.91	1.66			1.46	2.06	1.33
JAK1	NM_002227	9.72	7.84	3.29	28.88	9.80	11.17	18.75	6.19
KHSRP	NM_003685	0.42	1.03	0.91	0.61	1.15	0.75	1.07	1.62
MAPK9	NM_139070	1.16		1.62	1.68	1.83	0.00	2.51
METTL3	NM_019852	0.81	1.38	0.64	1.72	2.92	1.08	1.81	0.68
MRPL23	NM_021134	2.34	0.97	1.23	4.15	4.20	1.56	2.56	2.06
MRPS6	NM_032476	2.03	0.92	2.93	3.05	7.75	1.77	1.95	2.00
MRRF	NM_138777	10.11	13.30	3.96	2.03	9.28	1.33	9.70	7.34
MSN	NM_002444	3.20	1.66	1.81	9.47	7.86	3.13	8.58	2.12
MTMR6	NM_004685	3.71	11.73	2.61	7.73	7.33	2.67	14.97	2.58
NFKB1	NM_003998	3.74	0.91	0.65	8.83	6.51	4.10	7.30	1.55
NHLH1	NM_005589	26.32	37.92	49.09			66.39	51.25	126.29
NR1D2	NM_005126	1.40		2.31	4.57	3.69	1.27	2.50	2.29
NTE	NM_006702	1.75	0.31	0.89	3.92	4.37	1.30	3.87	1.43
NUFIP2	NM_020772	1.55	1.90	1.81	2.83	2.10	1.84	3.50	2.31
PAPOLA	NM_032632	0.47	0.52	0.29	0.79	4.73	0.58	1.25	0.32
PDCD2	NM_002598	3.83	3.44	2.94	5.00	5.74	5.88	5.36	7.37
PDCD6	NM_013232	1.96	2.72	2.53	2.16	4.79	2.69	2.85	2.16
PEX16	NM_004813	2.10	16.10	2.04	8.88	5.92	0.00	2.90	2.80
PGM2	NM_018290	3.23	3.62	2.16	5.99	5.72	4.89	6.13	3.36
PIK3R1	NM_181523	2.06	4.55	0.58	7.17	7.31	0.95	5.48	0.82
PKN1	NM_213560	2.25	3.76	1.27	6.67	6.09	2.39	8.14	2.84
POLR2G	NM_002696	1.09	5.58	2.06	1.91	6.01	2.60	3.82	2.91
PPP2R5C	NM_002719	2.78	2.62	1.28	9.50	6.14	1.63	7.87	0.84
PRKAA1	NM_006251	2.14	4.10	3.42	3.53	4.17	6.87	7.13	3.11
PRKAR1A	NM_002734	2.05	1.85	2.56	4.14	3.66	2.41	6.35	5.41
PUM2	NM_015317	2.81	1.69	0.87	2.85	5.04	1.49	3.84	2.22
RAP2C	NM_021183	2.69		2.56	4.75	5.35	25.28	10.61	1.95
REPIN1	NM_013400	2.37	3.85	3.12	1.92	6.62	8.53	7.06	6.52
RNF141	NM_16422	3.64	0.64	2.10	9.85	11.45	6.08	10.83	2.09
SELENBP1	NM_003944	7.88	9.51	3.46	22.18	7.54	2.84	7.65	5.70
SFXN1	NM_022754	1.37	3.46	1.58	1.35	1.40	1.67	1.99	1.72
SHPRH	NM_173082	0.82		1.07	0.21	7.17	0.00	0.64
SNAP23	NM_003825	3.46	0.45	1.89	12.62	13.33	4.15	10.19	1.43
SORL1	NM_003105	1.40	1.91	1.60			2.01	1.52	2.47
SOS1	NM_005633	0.70		0.81	1.69	1.09	0.29	1.61	0.90
TAF11	NM_005643	0.56		1.35	1.05	2.13	0.00	0.21	1.23
TCF3	NM_003200	2.00	0.94	1.08	2.83	3.96	3.54	2.52	2.65
TDP1	NM_018319	1.60	5.50	1.38	4.80	11.55	0.96	4.24
TNFRSF1A	NM_001065	11.96	4.07	1.36	18.01	13.25	3.30	17.81	2.06
UBTF	NM_014233	2.88	3.59	1.82	6.03	6.46	4.81	10.91	6.44
USP38	NM_032557	2.66		0.71	7.40	4.27	7.18	2.94	1.02
WAPAL	NM_015045	2.97		5.13	3.63	2.78	1.24	6.04	2.97
WDR26	NM_025160	0.84	0.09	0.63	2.18	1.53	0.80	2.74	1.23