Fold-difference values for 88 genes in each of eight subtypes (A–H) in 114 subtyped patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Genes without values for the subtypes are those for which there was missing data for one or more subtypes. Bold type indicates genes targeted by existing drugs and those CFS/ME subtypes in which fold-difference values of 1.5 were found
Gene symbol | Genbank accession | CFS/ME subtype | |||||||
A | B | C | D | E | F | G | H | ||
ABCD4 | NM_020323 | 1.40 | 0.60 | 0.81 | 4.40 | 10.61 | 7.02 | 1.32 | 0.93 |
ACTR3 | NM_005721 | 10.17 | 8.03 | 4.34 | 25.73 | 13.95 | 6.75 | 27.57 | 5.35 |
AKAP10 | NM_007202 | 3.83 | 3.25 | 1.68 | 8.39 | 5.59 | 6.61 | 4.89 | 1.64 |
ANAPC11 | NM_016476 | 2.53 | 2.66 | 4.34 | 3.74 | 1.59 | 4.16 | 2.27 | |
ANAPC5 | NM_016237 | 1.13 | 1.26 | 4.49 | 1.92 | 0.78 | 0.00 | 2.96 | 2.95 |
APP | NM_201413 | 0.63 | 1.73 | 1.42 | 0.56 | 4.64 | 0.84 | 0.84 | 2.58 |
ARL4C | NM_005737 | 6.62 | 7.40 | 2.72 | 5.85 | 7.82 | 8.76 | 6.68 | 2.81 |
ARPC5 | NM_005717 | 2.55 | 0.81 | 1.53 | 5.65 | 4.87 | 3.41 | 4.92 | 3.01 |
ARSD | NM_001669 | 0.64 | 1.17 | 1.51 | 4.60 | 2.62 | 0.26 | 0.12 | 2.19 |
ATP6V1C1 | NM_001695 | 1.99 | 3.80 | 3.38 | 2.43 | 2.06 | 0.72 | 3.63 | 4.55 |
BCOR | NM_017745 | 1.42 | 2.22 | 1.78 | 2.30 | 6.52 | 1.13 | 2.65 | 2.57 |
BMP2K | NM_198892 | 8.96 | 4.83 | 2.62 | 16.42 | 7.76 | 3.78 | 11.57 | 2.06 |
BRMS1 | NM_015399 | 1.31 | 4.38 | 2.44 | 1.53 | 4.62 | 7.06 | 2.57 | 3.83 |
CD2BP2 | NM_006110 | 3.89 | 1.37 | 2.21 | 6.77 | 4.52 | 1.33 | 5.99 | 3.55 |
CD47 | NM_198793 | 2.60 | 6.90 | 3.37 | 3.66 | 4.06 | 0.95 | 4.13 | 2.75 |
CEP350 | NM_014810 | 3.50 | 4.47 | 3.66 | 5.30 | 4.50 | 1.22 | 5.04 | 2.04 |
CITED2 | NM_006079 | 6.43 | 6.84 | 1.97 | 4.95 | 6.02 | 4.40 | 5.50 | 3.42 |
CMTM6 | NM_017801 | 3.10 | 3.70 | 0.69 | 10.04 | 7.81 | 4.77 | 1.71 | 0.73 |
CREBBP | NM_004380 | 7.11 | 1.62 | 1.09 | 13.34 | 5.46 | 2.61 | 8.99 | 3.62 |
CRK | NM_016823 | 1.83 | 5.57 | 1.26 | 2.82 | 4.89 | 1.03 | 2.25 | 2.02 |
CTBP1 | NM_001328 | 4.95 | 4.98 | 1.05 | 8.62 | 15.44 | 3.43 | 2.42 | 2.73 |
CXCR4 | NM_003467 | 13.47 | 2.18 | 2.03 | 28.10 | 17.57 | 1.48 | 10.29 | 3.57 |
EBI2 | NM_004951 | 5.67 | 1.41 | 2.31 | 14.93 | 5.99 | 0.76 | 0.42 | 4.47 |
EGR1 | NM_001955 | 0.49 | 2.85 | 2.42 | 0.30 | 0.27 | 1.00 | 1.98 | 2.96 |
EGR3 | NM_004421 | 0.95 | 1.33 | 0.46 | 5.36 | 1.39 | 0.98 | ||
EIF2B4 | NM_172195 | 1.44 | 0.52 | 1.33 | 6.00 | 3.48 | 0.15 | 1.69 | 2.08 |
EIF3S10 | NM_003750 | 1.43 | 4.42 | 2.10 | 1.72 | 1.48 | 1.25 | 2.83 | 6.16 |
EIF4G1 | NM_198241 | 1.13 | 3.47 | 3.52 | 0.99 | 1.39 | 2.30 | 4.53 | 14.27 |
EIF4G3 | NM_003760 | 2.40 | 0.79 | 0.77 | 5.46 | 27.42 | 1.09 | 3.62 | 1.55 |
ETS1 | NM_005238 | 35.12 | 4.63 | 4.16 | 52.65 | 30.36 | 17.54 | 24.17 | 6.91 |
FAM126B | NM_173822 | 2.04 | 0.63 | 0.91 | 10.18 | 5.51 | 2.59 | 1.31 | 0.71 |
FNTA | NM_002027 | 1.39 | 5.72 | 2.99 | 3.88 | 5.07 | 2.14 | 7.88 | 4.06 |
GABARAPL1 | NM_031412 | 6.08 | 6.42 | 3.37 | 2.93 | 8.49 | 2.58 | 6.23 | 5.74 |
GABPA | NM_002031 | 11.96 | 8.56 | 21.93 | 3.10 | 5.71 | 25.83 | 13.38 | 55.99 |
GCN1L1 | NM_006836 | 0.80 | 1.40 | 1.91 | 0.44 | 5.85 | 1.13 | 1.59 | 2.38 |
GLTSCR2 | NM_015710 | 3.68 | 2.46 | 0.53 | 4.94 | 6.98 | 4.07 | 10.28 | 0.80 |
GNAS | NM_080425 | 1.72 | 1.13 | 1.81 | 3.62 | 3.18 | 1.96 | 3.47 | 2.20 |
GSN | NM_198252 | 1.73 | 1.27 | 1.69 | 3.82 | 2.36 | 1.64 | 3.51 | 5.81 |
GTF2A2 | NM_004492 | 0.71 | 0.53 | 1.21 | 0.53 | 2.19 | 0.48 | 1.65 | 0.87 |
HIF1A | NM_001530 | 2.04 | 0.87 | 0.82 | 5.14 | 4.22 | 1.66 | 4.65 | 1.35 |
IFNAR1 | NM_000629 | 1.86 | 0.17 | 0.79 | 3.55 | 5.53 | 1.41 | 7.17 | 0.91 |
IL10RA | NM_001558 | 1.12 | 2.68 | 0.74 | 2.31 | 1.01 | 1.76 | ||
IL6R | NM_000565 | 2.19 | 2.47 | 2.78 | 2.67 | ||||
IL6ST | NM_002184 | 2.61 | 1.49 | 4.81 | 3.14 | 3.07 | 2.67 | 3.76 | |
IL7R | NM_002185 | 1.43 | 0.91 | 1.66 | 1.46 | 2.06 | 1.33 | ||
JAK1 | NM_002227 | 9.72 | 7.84 | 3.29 | 28.88 | 9.80 | 11.17 | 18.75 | 6.19 |
KHSRP | NM_003685 | 0.42 | 1.03 | 0.91 | 0.61 | 1.15 | 0.75 | 1.07 | 1.62 |
MAPK9 | NM_139070 | 1.16 | 1.62 | 1.68 | 1.83 | 0.00 | 2.51 | ||
METTL3 | NM_019852 | 0.81 | 1.38 | 0.64 | 1.72 | 2.92 | 1.08 | 1.81 | 0.68 |
MRPL23 | NM_021134 | 2.34 | 0.97 | 1.23 | 4.15 | 4.20 | 1.56 | 2.56 | 2.06 |
MRPS6 | NM_032476 | 2.03 | 0.92 | 2.93 | 3.05 | 7.75 | 1.77 | 1.95 | 2.00 |
MRRF | NM_138777 | 10.11 | 13.30 | 3.96 | 2.03 | 9.28 | 1.33 | 9.70 | 7.34 |
MSN | NM_002444 | 3.20 | 1.66 | 1.81 | 9.47 | 7.86 | 3.13 | 8.58 | 2.12 |
MTMR6 | NM_004685 | 3.71 | 11.73 | 2.61 | 7.73 | 7.33 | 2.67 | 14.97 | 2.58 |
NFKB1 | NM_003998 | 3.74 | 0.91 | 0.65 | 8.83 | 6.51 | 4.10 | 7.30 | 1.55 |
NHLH1 | NM_005589 | 26.32 | 37.92 | 49.09 | 66.39 | 51.25 | 126.29 | ||
NR1D2 | NM_005126 | 1.40 | 2.31 | 4.57 | 3.69 | 1.27 | 2.50 | 2.29 | |
NTE | NM_006702 | 1.75 | 0.31 | 0.89 | 3.92 | 4.37 | 1.30 | 3.87 | 1.43 |
NUFIP2 | NM_020772 | 1.55 | 1.90 | 1.81 | 2.83 | 2.10 | 1.84 | 3.50 | 2.31 |
PAPOLA | NM_032632 | 0.47 | 0.52 | 0.29 | 0.79 | 4.73 | 0.58 | 1.25 | 0.32 |
PDCD2 | NM_002598 | 3.83 | 3.44 | 2.94 | 5.00 | 5.74 | 5.88 | 5.36 | 7.37 |
PDCD6 | NM_013232 | 1.96 | 2.72 | 2.53 | 2.16 | 4.79 | 2.69 | 2.85 | 2.16 |
PEX16 | NM_004813 | 2.10 | 16.10 | 2.04 | 8.88 | 5.92 | 0.00 | 2.90 | 2.80 |
PGM2 | NM_018290 | 3.23 | 3.62 | 2.16 | 5.99 | 5.72 | 4.89 | 6.13 | 3.36 |
PIK3R1 | NM_181523 | 2.06 | 4.55 | 0.58 | 7.17 | 7.31 | 0.95 | 5.48 | 0.82 |
PKN1 | NM_213560 | 2.25 | 3.76 | 1.27 | 6.67 | 6.09 | 2.39 | 8.14 | 2.84 |
POLR2G | NM_002696 | 1.09 | 5.58 | 2.06 | 1.91 | 6.01 | 2.60 | 3.82 | 2.91 |
PPP2R5C | NM_002719 | 2.78 | 2.62 | 1.28 | 9.50 | 6.14 | 1.63 | 7.87 | 0.84 |
PRKAA1 | NM_006251 | 2.14 | 4.10 | 3.42 | 3.53 | 4.17 | 6.87 | 7.13 | 3.11 |
PRKAR1A | NM_002734 | 2.05 | 1.85 | 2.56 | 4.14 | 3.66 | 2.41 | 6.35 | 5.41 |
PUM2 | NM_015317 | 2.81 | 1.69 | 0.87 | 2.85 | 5.04 | 1.49 | 3.84 | 2.22 |
RAP2C | NM_021183 | 2.69 | 2.56 | 4.75 | 5.35 | 25.28 | 10.61 | 1.95 | |
REPIN1 | NM_013400 | 2.37 | 3.85 | 3.12 | 1.92 | 6.62 | 8.53 | 7.06 | 6.52 |
RNF141 | NM_16422 | 3.64 | 0.64 | 2.10 | 9.85 | 11.45 | 6.08 | 10.83 | 2.09 |
SELENBP1 | NM_003944 | 7.88 | 9.51 | 3.46 | 22.18 | 7.54 | 2.84 | 7.65 | 5.70 |
SFXN1 | NM_022754 | 1.37 | 3.46 | 1.58 | 1.35 | 1.40 | 1.67 | 1.99 | 1.72 |
SHPRH | NM_173082 | 0.82 | 1.07 | 0.21 | 7.17 | 0.00 | 0.64 | ||
SNAP23 | NM_003825 | 3.46 | 0.45 | 1.89 | 12.62 | 13.33 | 4.15 | 10.19 | 1.43 |
SORL1 | NM_003105 | 1.40 | 1.91 | 1.60 | 2.01 | 1.52 | 2.47 | ||
SOS1 | NM_005633 | 0.70 | 0.81 | 1.69 | 1.09 | 0.29 | 1.61 | 0.90 | |
TAF11 | NM_005643 | 0.56 | 1.35 | 1.05 | 2.13 | 0.00 | 0.21 | 1.23 | |
TCF3 | NM_003200 | 2.00 | 0.94 | 1.08 | 2.83 | 3.96 | 3.54 | 2.52 | 2.65 |
TDP1 | NM_018319 | 1.60 | 5.50 | 1.38 | 4.80 | 11.55 | 0.96 | 4.24 | |
TNFRSF1A | NM_001065 | 11.96 | 4.07 | 1.36 | 18.01 | 13.25 | 3.30 | 17.81 | 2.06 |
UBTF | NM_014233 | 2.88 | 3.59 | 1.82 | 6.03 | 6.46 | 4.81 | 10.91 | 6.44 |
USP38 | NM_032557 | 2.66 | 0.71 | 7.40 | 4.27 | 7.18 | 2.94 | 1.02 | |
WAPAL | NM_015045 | 2.97 | 5.13 | 3.63 | 2.78 | 1.24 | 6.04 | 2.97 | |
WDR26 | NM_025160 | 0.84 | 0.09 | 0.63 | 2.18 | 1.53 | 0.80 | 2.74 | 1.23 |