Table 4

Molecular analysis of IgVH genes

NoTotal no of clones analysedUnique sequences/totalPreferential IgVH gene usageMutated/total (%)Mutation mean (range)IgVH rearrangements Ag selected/totalOngoing mutationReceptor revision
1.229/22VH36/9 (67%)13.5 (3–20)2/9YesYes
2.1816/18VH3(3–66)13/16 (81%)13 (5–23)9/25NoNo
3.3129/31VH3(3–23)15/29 (52%)12.26 (5–29)6/29NoNo
4.3825/38VH3(3–23)9/25 (36%)8.25 (4–13)6/25NoNo
5.3829/38VH3(3–30)21/29 (73%)11.8 (7–22)9/29NoNo
6.3631/36VH3(3–15)20/31 (65%)9.9 (3–29)9/31NoNo
  • IgVH, immunoglobulin variable heavy.