Table 2

Comparison of HER2 status using SISH and FISH methodologies

ReferenceSample sizeNo. of test sitesConcordance (%)†κ coefficient*
Sinczak-Kuta61631NS0.38
Dietel et al7699596.00.75
Carbone et al6389598.9NS
Shousha et al7753194.0NS
Collins et al78230299.6NS
Bartlett et al7945796.0NS

  • FISH, fluorescence in situ hybridisation; SISH, silver in situ hybridisation; NS, not specified.

  • ↵* 95% confidence level unless otherwise specified, coefficients rounded to two decimal places.

  • ↵† Weighted averages were calculated in some instances.