Table 3

A summary of all patients with discordant results, including those where individual nodes were discordant although overall patient results were concordant

Patient no.GeneSearchHistopathologyCommentConcordance
14NegativeMicrometastasisD
69PositiveNegativeD
76PositivePositiveOne SLN was positive on both GeneSearch and histopathology but a second SLN was positive on GeneSearch onlyC
91PositiveNegativeD
116PositiveIsolated tumour cellsD
133PositiveNegativeTwo out of 18 nodes positive within immediate completion axillary clearanceC
152PositiveNegativeD
188NegativeNegativeOne cold undyed but palpable SLN was not submitted to GeneSearch but was positive on histopathologyD
190PositiveNegativeD
193PositiveNegativeD
194NegativeMicrometastasisD
196PositiveNegativeD
200PositiveNegativeOne out of six nodes positive within immediate completion axillary clearanceC
210PositiveNegativeD
223PositivePositiveOne SLN was positive on GeneSearch and isolated tumour cells were found on histopathology. A second SLN was negative on GeneSearch and contained a micrometastasis on histopathologyC
235PositivePositiveOne SLN was positive on GeneSearch and contained a micrometastasis on histopathology. A second SLN was negative on GeneSearch and contained isolated tumour cells on histopathologyC
236PositiveNegativeD
  • While the sensitivity of GeneSearch for detection of macrometastases in sentinel lymph nodes (SLNs) submitted for analysis was 100%, there was one palpable cold node that was not submitted for analysis in one patient, and this was the only histologically positive node in this patient.

  • C, concordant; D, discordant.