Table 1

Effect of several hormones on OPG/RANKL ratio

HormonesOPGRANKLOPG/RANKL
Oestrogen↑↓↑
Glucocorticoid↓↑↓
Parathyroid hormone* ↓↑↓
1,25(OH)2vitamin D↑↓↑

  • ↓, Decrease; ↑, Increase.

  • ↵* Continuous PTH exposure results in decrease OPG/RANKL ratio; however, intermittent exposure does not lead to significant alteration in OPG/RANKL ratio, while stimulating markers of bone formation.

  • OPG, osteoprotegerin; RANKL, receptor activator of NF-κβ ligand.