Typical immunophenotype of mucinous carcinomas of various organs
CK7 | CK20 | CEA | CA19.9 | CDX2 | CA125 | ER | DPC4 | p16 | |
Intestinal-type ovarian | D or F | F or D | F or D | D | F | N | N | D | N |
Mullerian-type ovarian | D | N | N | N or F | N | D | D | D | N |
Colorectal (including appendix) | N* | D | D | D | D | N | N | D | N or F |
Pancreatic | D or F | N or F | D or F | D | F | F or D | N | D or N | N |
Biliary | D or F | N or F | D or F | D | F | F or D | N | D or N | N |
Gastric | D or F | N or F | D or F | D | F | N | N | D | N |
Cervical | D | N or F | D or F | N | N or F | D | N or F | D | D† |
These represent the most typical immunostaining patterns but aberrant staining may occur in individual neoplasms.
↵* Rectal adenocarcinomas may be CK7 positive.
↵† Non-HPV-related cervical adenocarcinomas may be p16 negative.
CEA, carcinoembryonic antigen; D, diffusely positive; ER, oestrogen receptor; F, focally positive; HPV, human papillomavirus; N, negative.