Table 2

Overview of diagnostic features of six dermatopathology cases showing slight discrepancies when comparing diagnosis on conventional slides and whole slide digital images

Specimen type	Site	Clinical data	Original diagnosis	Digital diagnosis	Preferred diagnosis
Biopsy	Vulva	Patient known with differentiated VIN presented recently with hyperkeratosis, premalignant?	Lichen sclerosus	Lichen ruber	Digital
Biopsy	Toe	Hyperkeratotic papule below the nail of the fourth toe	Fibrokeratoma	Benign reactive verrucous lesion mostly verruca vulgaris	Original
Resection	Cheek	Reexcision after melanoma in situ with a focus of invasive growing. Radical? Rest of melanoma in situ?	There is no evidence of remnant melanoma with presence of small nevus in slide 3	No remnant of melanoma, no other specific abnormality	Original
Resection	Anus	Condyloma, anal flap. Condyloma?	Skin resection with viral changes and moderate dysplasia (AINII)	Anal intra-epithelial neoplasia grade III, probably HPV	Original
Resection	Nipple	Family history of melanoma, clinical diagnosis is nevus. Benign?	Melanocytic lesion difficult to classify, best diagnosed as irritated junctional nevus. Secondary diagnosis from the national panel was Spitz nevus	Skin excision nipple with dysplastic nevus	Original
Biopsy	Unknown	Skin papule, DD: nevus, BCC	Benign lichenoid keratosis	Eczema	Original

AIN II, Anal Intraepithelial Neoplasia grade II; BCC, Basal Cell Carcinoma; DD, Differential Diagnosis; HPV, Human Papilloma Virus; VIN, vulvar intraepithelial neoplasia;