Table 2

Overview of diagnostic features of six dermatopathology cases showing slight discrepancies when comparing diagnosis on conventional slides and whole slide digital images

Specimen typeSiteClinical dataOriginal diagnosisDigital diagnosisPreferred diagnosis
BiopsyVulvaPatient known with differentiated VIN presented recently with hyperkeratosis, premalignant?Lichen sclerosusLichen ruberDigital
BiopsyToeHyperkeratotic papule below the nail of the fourth toeFibrokeratomaBenign reactive verrucous lesion mostly verruca vulgarisOriginal
ResectionCheekReexcision after melanoma in situ with a focus of invasive growing. Radical? Rest of melanoma in situ?There is no evidence of remnant melanoma with presence of small nevus in slide 3No remnant of melanoma, no other specific abnormalityOriginal
ResectionAnusCondyloma, anal flap. Condyloma?Skin resection with viral changes and moderate dysplasia (AINII)Anal intra-epithelial neoplasia grade III, probably HPVOriginal
ResectionNippleFamily history of melanoma, clinical diagnosis is nevus. Benign?
  1. Melanocytic lesion difficult to classify, best diagnosed as irritated junctional nevus.

  2. Secondary diagnosis from the national panel was Spitz nevus

Skin excision nipple with dysplastic nevusOriginal
BiopsyUnknownSkin papule, DD: nevus, BCCBenign lichenoid keratosisEczemaOriginal
  • AIN II, Anal Intraepithelial Neoplasia grade II; BCC, Basal Cell Carcinoma; DD, Differential Diagnosis; HPV, Human Papilloma Virus; VIN, vulvar intraepithelial neoplasia;