Table 2

Downregulated genes in orbital fat from active thyroid associated orbitopathy compared with normal control tissue, as analysed using microarrays

Gene symbolGene descriptionFold changeEntrez ID
ADH1BAlcohol dehydrogenase 1B (class I), β polypeptide7.68125
FABP4Fatty acid binding protein 4, adipocyte5.852167
DKK3Dickkopf homologue 34.63*27122
C14orf180Chromosome 14 open reading frame 1804.28400258
AKR1C1Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-α (3-α)-hydroxysteroid dehydrogenase)3.731654
SFRP4Secreted frizzled-related protein 42.93* 6424
IL-17DInterleukin 17D2.7253342
CMBLCarboxymethylenebutenolidase homologue (Pseudomonas)2.69134147
MFAP5Microfibrillar associated protein 52.598076
ERAP2Endoplasmic reticulum aminopeptidase 22.5164167
BBS7Bardet–Biedl syndrome 72.4555212
FOXL2Forkhead box L22.41668
ITGBL1Integrin, β-like 1 (with EGF-like repeat domains)2.389358
DAAM1Dishevelled associated activator of morphogenesis 12.31*23002
TGFBR1Transforming growth factor, β receptor 12.297046
COL12A1Collagen, type XII, α 12.261303
IRS2Insulin receptor substrate 22.18 8660
IGFBP6Insulin-like growth factor binding protein 62.163489
PLCB1Phospholipase C, β 1 (phosphoinositide-specific)2.1223236
TMEM111Transmembrane protein 1112.0855831
WNT5AWingless-type MMTV integration site family, member 5A2.07* 7474
GSTM5Glutathione S-transferase mu 52.032949
FZD7Frizzled homologue 7 (Drosophila)2.02* 8324
  • Immunoglobulin superfamily, member

  • immunoglobulin superfamily, member 10

  • * Wnt pathway genes.

  • IGF-1 pathway genes.

  • Fold change validated by quantitative PCR.