Table 3

Micrometastases detected by histology and/or OSNA including the TAB cases

Reference (first author)TABMIC or OSNA+MICOSNA+Concordant MIC and OSNA+MIC overrated by OSNA++MIC underrated by OSNA−OSNA+ overrated as MACOSNA+ underrated as ITC/NEG
Tsujimoto1221551330264
Visser247261120542213
Schem251333924072717
Snook1817301227912810
Feldman271981435012922929
Bernet2881491052214
Le Frere-Belda1422471832369524
All8824610717637294138101
  • ITC, isolated tumour cells/clusters; MAC, macrometastasis (>2 mm); MIC, micrometastasis; NEG, negative by histology; OSNA+, one-step nucleic acid amplification positive with 250–5000 copies/μl; OSNA++, one-step nucleic acid amplification positive with >5000 copies/μl; OSNA−, one-step nucleic acid amplification negative with <250 copies/μl; TAB, tissue allocation bias.