Table 3

Upregulated genes in orbital fat from active thyroid associated orbitopathy compared with normal control tissue, as analysed using microarrays

Gene symbolGene descriptionFold changeEntrez ID
CD28CD28 molecule4.68940
SOCS3Suppressor of cytokine signalling 34.02* 9021
IL-7RInterleukin 7 receptor3.893575
IGF-1Insulin-like growth factor 1 (somatomedin C)2.97* 3479
SGK1Serum/glucocorticoid-regulated kinase 12.75* 6446
LYZLysozyme (renal amyloidosis)2.614069
AIF1Allograft inflammatory factor 12.50199
SLC20A1Solute carrier family 20 (phosphate transporter), member 12.416574
BCL11AB-cell CLL/lymphoma 11A (zinc finger protein)2.4053335
SLC2A14Solute carrier family 2 (facilitated glucose transporter), member 142.38144195
IFI16Interferon, γ-inducible protein 162.363428
SLC22A16Solute carrier family 22 (organic cation/carnitine transporter), member 162.3185413
CD300ACD300a molecule2.2411314
PTPRCProtein tyrosine phosphatase, receptor type, C2.235788
THY1Thy-1 cell surface antigen2.207070
JUNjun oncogene2.19*3725
ST8SIA4ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 42.147903
CLEC11AC-type lectin domain family 11, member A2.126320
IGLV1-44Immunoglobulin lambda variable 1-442.0628823
CTSCCathepsin C2.051075
IFNAR2Interferon (α, β and ω) receptor 22.023455
SLC20A1Solute carrier family 20 (phosphate transporter), member 12.016574
  • * IGF-1 pathway genes.

  • Fold change validated by quantitative PCR.