Table 1

Monoclonal plasma cell populations in the bone marrow and free light chain (FLC) concentrations in the serum of 54 patients with monoclonal gammopathy

Patient	Cell populations^*	BM infiltration^†	FLC only^‡	sFLK (mg/l)^§	sFLL (mg/l)^¶	sFLKL ratio^**	Paraprotein	Diagnosis
Single monoclonal cell population M-Ig
1	M-Ig	12%	2%	613	3	226.20	IgGK 28 g/l	Asymptomatic MM
2	M-Ig	11%	<1%	104	13	8.19	IgGK 16 g/l	Treated MM
3	M-Ig	64%	<1%	41	9	4.69	IgGK 39 g/l	New MM
4	M-Ig	<10%	4%	41	20	2.08	IgGK 19 g/l	New MGUS
5	M-Ig	90%	2%	23	2	14.29	IgGK 29 g/l	New MM
6	M-Ig	40%	2%	612	7	90.27	IgGK 33 g/l	New MM
7	M-Ig	5%	<1%	688	68	10.16	IgGK 7 g/l	New MGUS
8	M-Ig	42%	<1%	1	1	1.00	IgGK 23 g/l	New MM
9	M-Ig	10%	<1%	14	2	6.10	IgGK 21 g/l	New MM
10	M-Ig	15%	<1%	23	106	0.21	IgGL 18 g/l	MGUS
11	M-Ig	83%	<1%	1	1090	<0.01	IgGL 45 g/l	New MM
12	M-Ig	15%	<1%	7	83	0.09	IgGL 17 g/l	Asymptomatic MM
13	M-Ig	17%	2%	42	208	0.20	IgGL 18 g/l	AL amyloidosis
14	M-Ig	10%	<1%	3	27	0.10	IgGL 14 g/l	Relapsed MM
15	M-Ig	18%	<1%	10	12	0.82	IgGL 14 g/l	MGUS
16	M-Ig	26%	<1%	2	332	0.01	IgGL 28 g/l	New MM
17	M-Ig	49%	2%	29	3	11.60	IgAK 23 g/l	New MM
18	M-Ig	31%	<1%	1480	1	1057.14	IgAK 13 g/l	Multiply relapsed MM
19	M-Ig	19%	<1%	33	<1	370.00	IgAK 12 g/l	Treated MM
20	M-Ig	33%	<1%	122	2	70.93	IgAK 51 g/l	New MM
21	M-Ig	28%	<1%	51	6	7.92	IgAK 17 g/l	New MM
22	M-Ig	80%	<1%	9	773	0.10	IgAL 84 g/l	New MM
23	M-Ig	20%	<1%	5	387	0.01	IgAL 16 g/l	New MM
Dual monoclonal cell populations; M-Ig and FLC only
24	Dual M-Ig and FLC only	70%	13%	254	6	42.19	IgGK 28 g/l	New MM
25	Dual M-Ig and FLC only	50%	75%	15 300	16	944.45	IgGK 12 g/l	New MM
26	Dual M-Ig and FLC only	47%	10%	328	1	381.95	IgGK 50 g/l	New MM
27	Dual M-Ig and FLC only	70%	17%	1360	7	182.06	IgGK 17 g/l	New MM
28	Dual M-Ig and FLC only	40%	7%	1100	8	138.19	IgGK 50 g/l	New MM
29	Dual M-Ig and FLC only	10%	20%	14	223	0.06	IgGL 11 g/l	MGUS
30	Dual M-Ig and FLC only	19%	37%	23	801	0.08	IgGL 30 g/l	New MM
31	Dual M-Ig and FLC only	40%	91%	903	9	105.61	IgAK 2 g/l	New MM
32	Dual M-Ig and FLC only	20%	6%	0	275	0.01	IgAL 6 g/l	Treated MM
33	Dual M-Ig and FLC only	5%	7%	14	1970	0.01	IgAL 5 g/l	SP sternum
34	Dual M-Ig and FLC only	22%	23%	13	2640	0.01	IgDL 2 g/l	New MM
35	Dual M-Ig and FLC only	85%	53%	29 800	16	1862.5	Free KLCs	Light chain MM
36	Dual M-Ig and FLC only	70%	91%	34	17 100	0.01	Free LLCs	Light chain MM
37	Dual M-Ig and FLC only	60%	41%	13	15 500	0.01	Free LLCs	New MM, ARF
38	Dual M-Ig and FLC only	10%	58%	38	209	0.18	Free LLCs	FLC MGUS
Single monoclonal cell population; FLC only
39	FLC only	55%	95%	4140	1	5376.62	Free KLCs	New light chain MM
40	FLC only	50%	92%	3320	7	481.86	Free KLCs	New light chain MM
41	FLC only	10%	92%	585	14	42.09	Free KLCs	AL amyloidosis
42	FLC only	20%	56%	61	629	0.1	Free LLCs	AL amyloidosis
43	FLC only	18%	66%	32	3340	0.11	Free LLCs	New light chain MM
IgM monoclonal gammopathies
44	M-Ig	4%	<1%	67	6	11.18	IgMK 21 g/l	Untreated LL
45	M-Ig	20%	<1%	33	11	2.97	IgMK 36 g/l	New LL
46	M-Ig	Non-diagnostic	<1%	19	11	1.62	IgMK 20 g/l	IgM MGUS
47	M-Ig	16%	<1%	107	21	5.10	IgMK 11 g/l	New LL
48	M-Ig	42%	<1%	436	6	27.00	IgMK 12 g/l	Relapsed LL
49	M-Ig	<10%	<1%	22	10	2.18	IgMK 5 g/l	CHAD
50	M-Ig	29%	<1%	7	7	1.04	IgMK 20 g/l	New LL
51	M-Ig	20%	<1%	8	38	0.20	IgML 5 g/l	New LL
52	M-Ig	19%	<1%	12	101	0.10	IgML 16 g/l	New LL
53	Dual M-Ig and FLC only	62%	14%	36	13	2.02	IgMK 19 g/l	New LL
54	Dual M-Ig and FLC only	4% lymphocytes	45%	30	6	4.83	IgMK 5 g/l	Treated LGL, CHAD

↵* Monoclonal plasma cell populations found in marrow.
↵† Proportion of plasma cells in bone marrow.
↵‡ Proportion of plasma cells in marrow making free light chains only.
↵§ Concentration of free κ light chains in serum.
↵¶ Concentration of free λ light chains in serum.
↵** Ratio of free κ to free λ light chains in serum.
AL, amyloid light-chain; ARF, acute renal failure; CHAD, cold haemagglutinin disease; LGL, low grade lymphoma; LL, lymphoplasmacytic lymphoma; MGUS, monoclonal gammopathy of undetermined significance; MM, multiple myeloma; SP, solitary plasmacytoma.