Analysis of PTEN heterogeneity
| Case | Primary tumour slides, n (informative) | Metastasis, n (informative) | FISH interpretation average (PTEN/CEP10) | Result |
| 1 | 4 (2) | NA | 1–2/2–6 | All homogeneous |
| 2 | 5 (5) | 2 (2) (LN) | 1–3/3–8 | All homogeneous |
| 3 | 4 (4) | 8 (8) (LN) | 1–3/2–7 | Homogeneous deletion in primary tumour and 5/8 metastasis slides; in three metastasis slides polyploid PTEN/CEP10 with co-located cluster-like arrangement |
| 4 | 2 (2) | 1 (1) (LIV) | 0–2/2–7 | All homogeneous |
| 5 | NA | 1 (1) (LIV) | 1–3/2–8 | Homogeneous |
| 6 | 1 (1) | NA | 1–2/3–6 | Homogeneous |
| 7 | NA | 1 (1) (LN) | 1–2/4–8 | Homogeneous |
NA, no tumour or metastasis blocks available; LN, lymph node metastasis; LIV, liver metastasis.