Bilateral ovarian involvement | This may not result in bilateral ovarian enlargement, thereby appearing unilateral (eg in signet ring carcinoma) |
Maximum diameter <10 cm | About 15% tumours will not be correctly assigned on size and laterality criteria; cut-off points of 12 cm and 13 cm have been published, offering marginally better prediction; it has also been suggested that unilateral tumours 10–15 cm should be considered indeterminate |
Extensive intra-abdominal spread | An alternative primary site may not be found in all such cases; rare true disseminated ovarian mucinous primaries have been reported |
Multinodular growth pattern with intervening normal parenchyma | |
Surface involvement | |
Hilar involvement | |
Infiltrative pattern of small glands with desmoplastic reaction, single cell infiltration | |
Extensive vascular invasion | |
Extensive necrosis | Torsion should be excluded |
Patterns almost exclusive to metastasis: | Rare exceptions may occur, particularly in the presence of teratoma |
Signet ring carcinoma |
Pseudomyxoma peritonei (ovarii) |
Colloid carcinoma |
Resemblance of tumour to known primary | ‘Maturation’ in metastasis may cause metastasis to appear dissimilar |