Clinical and paraclinical data* | Active CD n=20 | Non-active CD n=20 | Control n=20 |
Mean age (months) | 57.4 (37.6) | 67.3 (38.4) | 54.0 (34.1) |
Sex (M/F) | 12 (60)/8 (40) | 11 (55)/9 (45) | 12 (60)/8 (40) |
Symptoms | |||
Abdominal pain | 5 (25) | 0 (0) | 0 (0) |
Diarrhoea | 8 (40) | 0 (0) | 0 (0) |
Weight loss | 11 (55) | 2 (16) | 0 (0) |
Anaemia | 6 (30) | 1 (5) | 0 (0) |
Iron deficiency | 4 (25) | 2 (10) | 0 (0) |
Anti-gliadin antibodies (AGA+) | 20 (100) | 0 (0) | N/A |
Anti-transglutaminase antibodies (tTG+) | 20 (100) | 0 (0) | N/A |
Duodenal biopsy† | |||
M0-1 | 0 (0) | 20 (100) | N/A |
M3 | 20 (100) | 0 (0) | N/A |
Human leucocyte antigen typing (DQ2/DQ8) | 20 (100) | 20 (100) | N/A |
↵* Data are expressed as absolute numbers and percentages related to the total numbers shown in brackets except for age, which is expressed as mean with its standard deviation in brackets.
↵† Modified Marsh classification of CD.19 M0, normal mucosa; M0-1, (infiltrative lesion) seen in patients on a gluten-free diet (suggesting minimal amounts of gliadin are being ingested), patients with dermatitis herpetiformis, and family members of patients with coeliac disease; M2, (hyperplastic type) seen occasionally in dermatitis herpetiformis; M3, >40 intraepithelial lymphocytes per 100 enterocytes, crypts increased and villi with atrophy (partial or complete villous atrophy) seen in cases of typical coeliac disease.
N/A, not applicable.