Clinicopathological summary of cases of mucosal large cell neuroendocrine carcinoma
| Case no | Age/sex | Site | pTN | Tx | Prognosis (months) | CD56 | ChA | Syn | TTF-1 | p63 | HMWK | N-cad | Ki-67 LI |
| 1 | 61/M | TB | T2N2c | S+R | DOAD (35 m) | f+ | – | ++ | – | ++ | ++ | – | 86.7% |
| 2 | 65/M | TB | T2N0 | S | DOD (50 m) | ++ | f+ | – | – | ++ | ++ | + | 90.8% |
| 3 | 63/M | LW | T2N2b | S+R | DOD (15 m) | ++ | ++ | ++ | ++ | – | – | ++ | 93.1% |
| 4 | 69/M | Larynx | T3N2b | S+C | DOD (25 m) | ++ | p+ | ++ | – | f+ | – | + | 78.1% |
| 5 | 67/M | Larynx | T4aN2c | S+C | AWOD (31 m) | ++ | – | ++ | – | p+ | f+ | ++ | 87.2% |
| 6 | 74/M | Larynx | T2N2c | S | AWOD (18 m) | ++ | f+ | – | – | + | f+ | + | 95.3% |
| 7 | 65/M | Larynx | T3N2b | S+C | AWOD (24 m) | ++ | f+ | + | + | f+ | – | – | 96.2% |
| 8 | 52/M | Hypo | T2N1 | S+C | AWOD (90 m) | ++ | – | ++ | – | f+ | – | + | 92.8% |
AWOD, alive without disease; C, chemotherapy; ChA, chromogranin-A; DOAD, died of another disease; DOD, died of disease; HMWK, high molecular weight keratin; hypo, hypopharynx; Ki-67 LI, Ki-67 labelling index; LW, lateral wall of the oropharynx; N-cad, N-cadherin; R, radiotherapy; S, surgery; Syn, synaptophysin; TB, tongue base; TTF-1, thyroid transcription factor-1; Tx, treatment.
−, negative; f+, focally positive (<10% positive); p+, partially positive (10–19% positive); +, positive (20%–49% positive); ++, diffusely and strongly positive (>50% positive).