Univariate and multivariable analysis of prognostic factors in hepatocellular carcinoma for 5-year survival
| Univariate analysis | Multivariable analysis (adjusted for age and sex) | |||||
| HR | p >|z| | 95% CI | HR | p >|z| | 95% CI | |
| FOXP1 expression | ||||||
| High vs low | 1.917 | 0.046* | 1.012 to 3.633 | 2.182 | 0.018* | 1.146 to 4.154 |
| Gender | ||||||
| Male vs Female | 1.651 | 0.189 | 0.781 to 3.492 | – | ||
| Age (years) | ||||||
| <40 vs 40–60 and >60 | 1.341 | 0.218 | 0.841 to 2.140 | – | ||
| Tumour diameter (cm) | ||||||
| ≥5 vs <5 | 2.167 | 0.099 | 0.865 to 5.431 | – | ||
| Differentiation | ||||||
| Well–Moderate vs poorly | 1.893 | 0.019* | 1.112 to 3.220 | 1.732 | 0.058 | 0.982 to 3.057 |
| α-fetoprotein (ng/ml) | ||||||
| <50 vs 50–900 and >900 | 1.328 | 0.089 | 0.958 to 1.842 | – | ||
| Liver cirrhosis | ||||||
| Yes vs No | 1.898 | 0.094 | 0.898 to 4.012 | – | ||
| Portal vein invasion | ||||||
| Yes vs No | 1.848 | 0.027* | 1.071 to 3.190 | 0.929 | 0.873 | 0.379 to 2.280 |
| Regional lymph node metastasis | ||||||
| Yes vs No | 2.920 | 0.001* | 1.561 to 5.461 | 2.326 | 0.041* | 1.037 to 5.217 |
| Tumour with a complete fibrous capsule | ||||||
| Yes vs No | 1.586 | 0.084 | 0.939 to 2.677 | |||
| Gross classification | ||||||
| Multifocal vs unifocal | 2.119 | 0.006* | 1.243 to 3.612 | 1.638 | 0.203 | 0.767 to 3.500 |
| Hepatitis B virus infection | ||||||
| Yes vs No | 1.419 | 0.315 | 0.717 to 2.810 | |||
| Stage grouping with TNM | ||||||
| Stage I–II vs Stage III | 2.074 | 0.007* | 1.226 to 3.508 | 1.187 | 0.727 | 0.453 to 3.105 |
↵* p<0.05.
FOXP1, Forkhead Box P1; TNM, tumour node metastasis.