Table 4

Original and light microscopic diagnosis of the light microscopically discrepant cases

Case	Site	Clinical diagnosis	Original light microscopic diagnosis	Second light microscopic diagnosis	Discrepancy type
1	Oesophagus	History of eosinophilic oesophagitis, eosinophilia? Inflammation?	Eosinophilic oesophagitis	Massive eosinophilic infiltration, not enough for eosinophilic oesophagitis but consistent with reflux	Mild
2	Placenta	Missed abortion, trophoblastic changes or other abnormality?	Parts of first trimester pregnancy with degenerative changes and signs of IUFD and parenchyma changes suggestive of CHX abnormality	First trimester parenchymal tissue with a signs of IUFD	Mild
3	Placenta	Premature delivery, placental abnormality?	Extensive chorioamnionitis especially in the chorionic plate, and features suggestive of CAOS	No inflammation, no ischaemia, no villitis, some degenerative changes in the membranes, iron deposition in chorionic plate. The picture is consistent with mild COAS	Mild
4	Placenta	Spontaneous abortion, abnormalities?	35 weeks placenta with less than 5% micro-infarction, no other abnormality seen	Grade one chronic villitis, ischaemia and small infarction, normal maturation (close to term)	Mild
5	Placenta	Premature delivery. Chorioamnionitis?	Placenta with normal weight and first signs of chorioamnionitis	Normal for gestational age, no inflammation, no funiculitis, no chorioamnionitis	Mild
6	Placenta	Dichorionic diamniotic twin pregnancy, IUGR	Mild chorioamnionitis and chronic villitis from unknown aetiology	Bichorionic placenta. The first part shows some increase in the maturation. The second placenta shows more advanced maturation and mild chronic villitis.	Mild
7	Placenta	Diabetic and hypertensive mother, pre-eclampsia? Infarction?	Placenta, mild chorioamnionitis and infarction	Recent and old infarction, no signs of maternal diabetes	Mild

WSI, whole slide images.