Clinicopathologic features of MMF-associated colitis
| Clinicopathologic features | Case | ||||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | |
| Age/sex | 42 F | 63 M | 49 M | 41 F | 51 M | 24 F | 53 F |
| Transplant organ | Kidney | Liver | Bone marrow | Kidney | Kidney | Kidney | Kidney |
| Presenting symptom | Diarrhoea | Diarrhoea | Diarrhoea | Diarrhoea | Diarrhoea | Diarrhoea | Diarrhoea |
| Total biopsy fragments | 16 | 4 | 12 | 13 | 5 | 22 | 7 |
| % Biopsy fragments with IBD-like changes | 68.7 | 75 | 75 | 38.5 | 60 | 27.3 | 85.7 |
| Foci of cryptitis | 3 | 2 | 1 | 7 | 1 | 6 | 1 |
| Acute self-limiting colitis | 0 | 0 | 8 | 6 | 0 | 1 | 0 |
| Foci of IDC | 8 | 6 | 6 | 10 | 4 | 30 | 12 |
| Apoptosis (/100 crypts) | 24 | 28 | 24 | 38 | 40 | 12 | 20 |
FAC, focal active colitis; IBD, inflammatory bowel disease; IDC, isolated damaged crypt; MMF, mycophenolate mofetil.