Table 2

Correlations between IGFBP-5 expression and other important clinicopathological parameters in urothelial carcinomas

Upper urinary tract urothelial carcinomaUrinary bladder urothelial carcinoma
IGFBP-5 expressionIGFBP-5 expression
ParameterCategoryCase no.LowHighp ValueCase no.LowHighp Value
GenderMale18290920.8282161071090.868
Female1588078794039
Age (years)<6513864740.26912157640.435
≥65202106961749084
Tumour locationRenal pelvis14169720.262
Ureter1508169
Renal pelvis and ureter492029
MultifocalitySingle2781451330.092
Multifocal622537
Primary tumour (T)Ta897613<0.001*845826<0.001*
T1925042885038
T2–T4159441151233984
Nodal metastasisNegative (N0)3121631490.006*2661401260.004*
Positive (N1–N2)2872129722
Histological gradeLow grade564214<0.001*5635210.035*
High grade284128159239112127
Vascular invasionAbsent23413995<0.001*2461321140.003*
Present1063175491534
Perineural invasionAbsent3211651560.034*2751421330.021*
Present1951420515
Mitotic rate (per 10 high power fields)<1017310370<0.001*13979600.023*
≥10167671001566888
  • *Statistically significant.