Table 4

Univariate log-rank and multivariate analyses for disease-specific and metastasis-free survivals in urinary bladder urothelial carcinoma

Disease-specific survivalMetastasis-free survival
Univariate analysisMultivariate analysisUnivariate analysisMultivariate analysis
ParameterCategoryCase no.No. of eventp ValueRR95% CIp ValueNo. of eventp ValueRR95% CIp Value
GenderMale216390.5392590.2999
Female791116
Age (years)<65121160.097210.283300.5912
≥65174341.4450.784 to 2.66345
Primary tumour (T)Ta841<0.0001*1<0.001*4<0.0001*10.008*
T18895.7160.593 to 55.089234.4931.282 to 15.739
T2–T41234022.3852.435 to 205.761486.8731.961 to 24.083
Nodal metastasisNegative (N0)266410.0037*10.69861<0.0001*10.073
Positive (N1–N2)2991.1640.540 to 2.511141.7960.946 to 3.408
Histological gradeLow grade5620.0017*10.85050.0008*10.798
High grade239480.8550.169 to 4.336750.8660.288 to 2.606
Vascular invasionAbsent246360.0052*10.492540.0003*10.878
Present49141.2950.370 to 1.613211.0500.563 to 1.959
Perineural invasionAbsent275440.0085*10.426650.0006*10.215
Present2061.4790.565 to 3.873101.6010.762 to 3.365
Mitotic rate (per 10 high power fields)<1013912<0.0001*10.042*22<0.0001*10.026*
≥10156382.0421.28 to 4.059531.8221.073 to 3.094
IGFBP-5 expressionLow147110.0001*10.026*20<0.0001*10.032*
High148392.2001.101 to 4.395551.7461.050 to 2.905
  • *Statistically significant.