Table 3

Univariate log-rank and multivariate analyses for disease-specific and metastasis-free survivals in upper urinary tract urothelial carcinoma

Disease-specific survivalMetastasis-free survival
Univariate analysisMultivariate analysisUnivariate analysisMultivariate analysis
ParameterCategoryCase No.No. of eventp ValueRR95% CIp ValueNo. of eventp ValueRR95% CIp Value
GenderMale158280.8286320.7904
Female1823338
Age (years)<65138260.9943300.8470
≥652023540
Tumour sideRight177340.7366380.3074
Left1542632
Bilateral910
Tumour locationRenal pelvis141240.0079*10.941310.065910.961
Ureter150220.7880.424 to 1.464251.1940.379 to 3.763
Renal pelvis and ureter49151.4520.405 to 5.210141.0910.326 to 3.658
MultifocalitySingle273480.0026*10.009*520.0127*10.011*
Multifocal62182.7201.285 to 5.756182.6541.253 to 5.620
Primary tumour (T)Ta892<0.0001*10.1354<0.0001*10.143
T19292.7890.586 to 13.267152.9640.943 to 9.315
T2–T4159503.5140.746 to 16.559512.4270.727 to 8.102
Nodal metastasisNegative (N0)31242<0.0001*1<0.001*55<0.0001*1<0.001*
Positive (N1–N2)28195.0592.737 to 9.352155.0892.753 to 9.405
Histological gradeLow grade5640.0215*10.016*30.0027*10.013*
High grade284573.3561.255 to 8.979673.5461.308 to 9.611
Vascular invasionAbsent23424<0.0001*10.19226<0.0001*10.166
Present106371.4900.818 to 2.712441.5360.837 to 2.818
Perineural invasionAbsent32150<0.0001*1<0.001*61<0.0001*1<0.001*
Present19113.8221.825 to 8.00393.8051.816 to 7.974
Mitotic rate (per 10 high power fields)<10173270.167300.082310.553
≥1016734400.8510.499 to 1.451
IGFBP-5 expressionLow17010<0.0001*10.03120<0.0001*10.032*
High170512.2591.076 to 4.744502.2541.074 to 4.732
  • *Statistically significant.