Table 2

Concordance of histological findings associated with the blood and lymphatic vessel invasion

Histological findingsκ Value95% CI
Cohort 2
 Presence of space around tumour nests0.4920.424 to 0.560
 Presence of endothelium around tumour nests0.5180.451 to 0.586
 Presence of vascular smooth muscle around tumour nests0.4120.344 to 0.479
 Presence of spicula at the periphery of tumour nests0.3080.240 to 0.376
 Presence of lymphatic fluid in peritumoural space0.4540.386 to 0.522
 Presence of blood cells in peritumoural space0.3950.327 to 0.462
 Difficult to distinguish blood and lymphatic vessel0.064−0.033 to 0.132
 Presence of continuity in normal blood or lymphatic vessel0.2760.209 to 0.344
Cohort 4
 Presence of space around tumour nests0.4710.404 to 0.539
 Presence of endothelium around tumour nests0.2690.201 to 0.336
 Presence of vascular smooth muscle around tumour nests0.3720.305 to 0.440
 Presence of spicula at the periphery of tumour nests0.002−0.066 to 0.069
 Presence of lymphatic fluid in peritumoural space0.1420.075 to 0.210
 Presence of blood cells in peritumoural space0.055−0.013 to 0.122
 Difficult to distinguish blood and lymphatic vessel0.055−0.013 to 0.123
 Presence of continuity in normal blood or lymphatic vessel0.1500.082 to 0.217
 Growth along with normal artery0.4910.424 to 0.559
 Presence of elastica-stained internal elastic membrane covering more than half of the circumference surrounding the tumour cluster0.8010.734 to 0.869
 Presence of D2-40 positive cells covering more than half of the circumference surrounding the tumour cluster0.4510.383 to 0.518
 Presence of D2-40 positive endothelial cells covering more than half of the circumference surrounding the tumour cluster0.6820.615 to 0.750