Characteristics and outcome of patients operated for primary aldosteronism
| Patient data | Pathology data | Immunohistochemistry | Follow up | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Group | n | Gender | Age | Size of adenoma or largest nodule (mm) | Pathology diagnosis (using routine H&E staining) | Largest nodule | Comments | Cure of PA | Months | Final diagnosis |
| A | 36 | F | 16 | 15 | Adenoma | B2+, B1+ | Nodules B1+ | Yes | 30 | Aldosterone-producing adenoma |
| A | 44 | F | 34 | 9 | Adenoma | B2+, B1+ | Nodules B1+ | Yes | 60 | Aldosterone-producing adenoma |
| A | 57 | F | 46 | 47 | Adenoma | B2+, B1+ | Yes | 6 | Aldosterone-producing adenoma | |
| A | 73 | F | 61 | 35 | Hyperplasia or adenoma | B2+, B1+ | 9 and 5 mm nodule B1+, APCC | Yes | 66 | Aldosterone-producing adenoma |
| A | 79 | M | 64 | 13 | Adenoma and surrounding nodular cortical hyperplasia | B2+, B1+ | Nodules B1+ | Yes | 48 | Aldosterone-producing adenoma |
| A | 80 | M | 50 | 20 | Adenoma | B2+, B1+ | Nodules B1+ | Yes | 30 | Aldosterone-producing adenoma |
| A | 82 | M | 51 | 12 | Adenoma and surrounding nodular cortical hyperplasia | B2+, B1+ | Nodules B1+ | Yes | 4 | Aldosterone-producing adenoma |
| A | 86 | F | 50 | 11 | Adenoma | B2+, B1+ | APCC | Yes | 1 | Aldosterone-producing adenoma |
| A | 90 | M | 53 | 18 | Adenoma | B2+, B1+ | Yes | 7 | Aldosterone-producing adenoma | |
| A | 98 | M | 42 | 12 | Adenoma and surrounding nodular cortical hyperplasia | B2+, B1+ | Nodules B1+ | Yes | 25 | Aldosterone-producing adenoma |
| A | 120 | M | 34 | 15 | Adenoma | B2+, B1+ | Nodules B1+ | Yes | 18 | Aldosterone-producing adenoma |
| A | 75 | M | 63 | 10 | Hyperplasia or adenoma | B2+, B1− | Nodules B1+ | Yes | 48 | Aldosterone-producing adenoma |
| A | 89 | M | 44 | 13 | Adenoma | B2+, B1− | Yes | 54 | Aldosterone-producing adenoma | |
| A | 95 | M | 48 | 13 | Adenoma and surrounding nodular cortical hyperplasia | B2+, B1− | Nodules B1+ | Yes | 34 | Aldosterone-producing adenoma |
| A | 97 | F | 22 | 20 | Adenoma and surrounding nodular cortical hyperplasia | B2+, B1− | Nodules B1+ | Yes | 35 | Aldosterone-producing adenoma |
| A | 100 | F | 47 | 23 | Adenoma and surrounding nodular cortical hyperplasia | B2+, B1− | Nodules B1+ | Yes | 1 | Aldosterone-producing adenoma |
| A | 109 | M | 54 | 9 | Adenoma or hyperplasia | B2+, B1− | Yes | 24 | Aldosterone-producing adenoma | |
| B | 27 | M | 61 | 25 | Adenoma | B2−, B1+ | Nodules B2+ | No | 132 | Nodular aldosterone-producing hyperplasia. Non-hyper-functioning cortisol-producing nodule. |
| B | 81 | M | 63 | 10 | Adenoma and surrounding nodular cortical hyperplasia | B2−, B1+ | Nodules B2+ Nodules B1+ | Yes | 60 | Nodular aldosterone- producing hyperplasia. Non- hyperfunctioning |
| cortisol-producing nodule | ||||||||||
| B | 96 | F | 56 | 16 | Adenoma and surrounding nodular cortical hyperplasia | B2−, B1+ | Nodules B2+ Nodules B1+ | Yes | 16 | Nodular aldosterone-producing hyperplasia. Non-hyperfunctioning cortisol-producing nodule |
| C | 34 | M | 68 | – | Hyperplasia | – | Nodules B2+ | No | 144 | Nodular aldosterone-producing hyperplasia. |
| C | 46 | M | 71 | – | Hyperplasia | – | Nodules B2+ | No | 6 | Nodular aldosterone-producing hyperplasia. |
| C | 87 | M | 50 | – | Hyperplasia | – | Nodules B2+ | No | 45 | Nodular aldosterone-producing hyperplasia. |
| C | 116 | M | 41 | – | Hyperplasia | – | Nodules B2+ Nodules B1+ | Yes | 24 | Nodular aldosterone-producing hyperplasia. |
APA, aldosterone-producing adenoma; APCC, aldosterone-producing cell cluster; B1, CYP11B1; B2, CYP11B2; n, identification number; PA, primary aldosteronism.