Table 1

Summary of differentially expressed genes associated with regulation of cell growth in the transcriptome of urothelial carcinoma of urinary bladder

ProbeComparison log ratioComparison p valueGene symbolGene nameBiological processCellular componentMolecular function
211959_at3.3334<0.0001IGFBP5Insulin-like growth factor-binding protein 5Regulation of cell growth, signal transductionEndoplasmic reticulum, extracellular regionGrowth factor binding, insulin-like growth factor binding
203424_s_at1.7363<0.0001IGFBP5Insulin-like growth factor-binding protein 5Regulation of cell growth, signal transductionEndoplasmic reticulum, extracellular regionGrowth factor binding, insulin-like growth factor binding
201185_at1.44910.0001HTRA1HtrA serine peptidase 1Negative regulation of bone morphogenetic protein signalling pathway, negative regulation of transforming growth factor β-receptor signalling pathway, proteolysis and regulation of cell growthExtracellular region, extracellular spaceGrowth factor binding, hydrolase activity, insulin-like growth factor binding, peptidase activity, protein binding, serine-type endopeptidase activity
209550_at1.3548<0.0001NDNNecdin homologue (mouse)Axon extension involved in development, axonal fasciculation, axonogenesis, central nervous system development, glial cell migration, negative regulation of cell proliferation, nerve growth factor receptor signalling pathway, nervous system development, neuron development, neuron migration, regulation of cell growth, regulation of progression through cell cycle, regulation of transcription, DNA dependent, respiratory gaseous exchange, sensory perception of pain and transcriptionCentrosome, cytoplasm, nucleusDNA binding, γ-tubulin binding, protein binding
211958_at1.310.0001IGFBP5Insulin-like growth factor binding protein 5Regulation of cell growth, signal transductionEndoplasmic reticulum, extracellular regionGrowth factor binding, insulin-like growth factor binding
202177_at1.11960.0003GAS6growth arrest-specific 6Cell proliferation, regulation of cell growth, signal transductionExtracellular regionCalcium ion binding, metal ion binding, receptor binding
210764_s_at0.97060.0014CYR61Cysteine-rich; angiogenic inducer; 61Anatomical structure morphogenesis, cell adhesion, cell proliferation, chemotaxis, patterning of blood vessels, regulation of cell growthExtracellular regionGrowth factor binding, heparin binding, insulin-like growth factor binding, protein binding
209648_x_at0.95990.0002SOCS5Suppressor of cytokine signalling 5Cell growth, cytokine and chemokine-mediated signalling pathway, epidermal growth factor receptor signalling pathway, intracellular signalling cascade, negative regulation of T-helper 2 cell differentiation, negative regulation of signal transduction, positive regulation of T-helper 1 cell differentiation, regulation of cell growthEpidermal growth factor receptor binding, protein binding
203851_at0.95350.0003IGFBP6Insulin-like growth factor binding protein 6Negative regulation of cell proliferation, regulation of cell growth, signal transductionExtracellular region, extracellular spaceGrowth factor binding, insulin-like growth factor binding
208127_s_at0.9260.0012SOCS5Suppressor of cytokine signalling 5Cell growth, cytokine and chemokine-mediated signalling pathway, epidermal growth factor receptor signalling pathway, intracellular signalling cascade, negative regulation of T-helper 2 cell differentiation, negative regulation of signal transduction, positive regulation of T-helper 1 cell differentiation, regulation of cell growthEpidermal growth factor receptor binding, protein binding
201162_at0.83150.0004IGFBP7Insulin-like growth factor binding protein 7Negative regulation of cell proliferation, regulation of cell growthExtracellular regionGrowth factor binding, insulin-like growth factor binding, protein binding
221381_s_at0.82140.0015MORF4Mortality factor 4, mortality factor 4 like 1Ageing, cell proliferation, chromatin assembly or disassembly, chromatin modification, regulation of cell growth, regulation of transcription, DNA dependent, transcriptionChromatin, nucleusChromatin binding, protein binding, transcription factor activity
224561_s_at0.69760.0051MORF4L1Mortality factor 4 like 1Ageing, cell proliferation, chromatin assembly or disassembly, chromatin modification, regulation of cell growth, regulation of transcription; DNA dependent, transcriptionChromatin, nucleusChromatin binding, protein binding, transcription factor activity
206796_at0.656<0.0001WISP1WNT1-inducible signalling pathway protein 1Wnt receptor signalling pathway, cell adhesion, cell–cell signalling, regulation of cell growth, signal transductionExtracellular region, soluble fractionInsulin-like growth factor binding, protein binding
204471_at0.64940.002GAP43Growth-associated protein 43Cell differentiation, multicellular organismal development, nervous system development, protein kinase C activation, regulation of cell growth, regulation of growth, response to woundingCell junction, cell projection, membrane, plasma membrane, synapseCalmodulin binding, protein binding
1555997_s_at0.6237<0.0001IGFBP5Insulin-like growth factor-binding protein 5Regulation of cell growth, signal transductionEndoplasmic reticulum, extracellular regionGrowth factor binding, insulin-like growth factor binding
214321_at0.50510.0098NOVNephroblastoma overexpressed geneRegulation of cell growthExtracellular regionGrowth factor activity, insulin-like growth factor binding
227760_at0.45790.0014IGFBPL1Insulin-like growth factor-binding protein-like 1Regulation of cell growthExtracellular regionInsulin-like growth factor binding
228580_at0.31840.0039HTRA3HtrA serine peptidase 3Proteolysis, regulation of cell growthExtracellular regionHydrolase activity, insulin-like growth factor binding, peptidase activity, protein binding, serine-type endopeptidase activity
205792_at0.28560.0056WISP2WNT1-inducible signalling pathway protein 2Cell adhesion, cell–cell signalling, regulation of cell growth, signal transductionExtracellular region, plasma membrane, soluble fractionInsulin-like growth factor binding, protein binding
214159_at−0.30520.0001PLCE1Phospholipase C; epsilon 1G-protein signalling; coupled to IP3 s messenger (phospholipase C activating), Ras protein signal transduction, activation of mitogen-activated protein kinase activity, calcium-mediated signalling, cell proliferation, cytoskeleton organisation and biogenesis, diacylglycerol biosynthetic process, elevation of cytosolic calcium ion concentration, epidermal growth factor receptor signalling pathway, heart development, inositol phosphate-mediated signalling, intracellular signalling cascade, lipid catabolic process, lipid metabolic process, phospholipid metabolic process, protein kinase C activation, regulation of G-protein coupled receptor protein signalling pathway, regulation of Ras protein signal transduction, regulation of cell growth, regulation of protein kinase activity, regulation of smooth muscle contraction, signal transduction, small GTPase-mediated signal transductionCytoplasm, cytosol, intracellular, membrane, membrane fraction, plasma membraneRas GTPase binding, calcium ion binding, enzyme binding, guanyl-nucleotide exchange factor activity, hydrolase activity, phosphoinositide phospholipase C activity, phospholipase C activity, protein binding, receptor signalling protein activity, signal transducer activity
1569020_at−0.39560.001NEDD9Neural precursor cell expressed; developmentally downregulated 9Actin filament bundle formation, cell adhesion, cell cycle, cell division, cytoskeleton organisation and biogenesis, integrin-mediated signalling pathway, mitosis, regulation of cell growth, regulation of progression through cell cycle, signal transductionCell junction, cell projection, cytoplasm, cytoskeleton, nucleus, spindleProtein binding
235857_at−0.53480.0091KCTD11Potassium channel tetramerisation domain containing 11cell cycle, intracellular signalling cascade, multicellular organismal development, negative regulation of progression via cell cycle, potassium ion transport, regulation of GTPase activity, regulation of cell growth, signal transductionMembrane, voltage-gated potassium channel complexGTPase activator activity, metal ion binding, phospholipase C activity, protein binding, voltage-gated potassium channel activity, zinc ion binding
208394_x_at−0.83170.0024ESM1Endothelial cell-specific molecule 1Regulation of cell growthExtracellular regionGrowth factor activity, insulin-like growth factor binding, protein binding
210095_s_at−1.5251<0.0001IGFBP3Insulin-like growth factor-binding protein 3Negative regulation of signal transduction, positive regulation of apoptosis, positive regulation of myoblast differentiation, regulation of cell growthExtracellular regionGrowth factor binding, insulin-like growth factor binding, metal ion binding, protein binding, protein tyrosine phosphatase activator activity
212143_s_at−1.7055<0.0001IGFBP3Insulin-like growth factor-binding protein 3Negative regulation of signal transduction, positive regulation of apoptosis, positive regulation of myoblast differentiation, regulation of cell growthExtracellular regionGrowth factor binding, insulin-like growth factor binding, metal ion binding, protein binding, protein tyrosine phosphatase activator activity