Table 7

Some features which may be useful for initial diagnosis and classification of IBD

FeatureIBD>infectiveInfective>IBDUC>CDCD>UC
Architecture
 Preserved architecture+ + ++
 Crypt distortion+ + ++ +
 Crypt atrophy+ + ++ +
 Diffuse intersite or intrasite crypt changes (in IBD)+ + +
 Non-diffuse crypt changes (in IBD)+
 Irregular mucosal surface+ + ++ +
Inflammation
 Basal plasmacytosis+ + +
 Lymphoid aggregates+ +
 Diffuse intersite or intrasite CI (in IBD)+ + +
 Non-diffuse/focal CI (in IBD)+ +
 Inflammation upper LP+
 Granulomas (non-cryptolytic)+ ++ + + +
 LP acute inflammation (no CI)+
 Widespread cryptitis (in IBD)+
Other changes
 Mucin depletion+ +
 Paneth cell metaplasia+
 Ileal inflammation (in IBD)+ +
  • + + + +, very strongly discriminant; + + +, highly discriminant; + +, moderately discriminant; +, weakly discriminant; CD: Crohn's disease; CI: chronic inflammation; IBD, inflammatory bowel disease; LP: lamina propria; UC: ulcerative colitis.