Table 6

Head to head comparison of simple panels used to identify patients with fibrosis

Score	AUROC (95% CI)	Cut-off	Se (%)	Sp (%)	PPV (%)	NPV (%)
AAR	0.83 (0.74 to 0.91)	0.8	74	78	44	93
AAR	0.83 (0.74 to 0.91)	1.0	52	90	55	89
APRI	0.67 (0.54 to 0.8)	1	27	89	37	84
BARD	0.77 (0.68 to 0.87)	2	89	44	27	95
FIB-4	0.86 (0.78 to 0.94)	1.30	85	65	36	95
NAFLD Fibrosis Score	0.81 (0.71 to 0.91)	−1.455	78	58	30	92
NAFLD Fibrosis Score	0.81 (0.71 to 0.91)	0.676	33	98	79	86

Modified from McPherson and colleagues,57 with permission.
AAR, AST to ALT ratio; ALT, alanine aminotransferase; APRI, AST to Platelet Ratio Index; AST, aspartate aminotransferase; AUROC, area under the receiver operating characteristic curve; NAFLD, non-alcoholic fatty liver disease; NPV, negative predictive value; PPV, positive predictive value; Se, sensitivity; Sp, speciﬁcity.