Table 1

Details of cohorts and concordance of blood and lymphatic vessel invasion (BLI)

H&E staining	D2-40 and elastica staining	Designated area of lesion	Criterion		κ Value	95% CI	Positive ratio (%)
Cohort 1
+	−	−	−	Agreement in blood vessel invasion	0.524	0.441 to 0.606	28.1
+	−	−	−	Agreement in lymphatic vessel invasion	0.216	0.133 to 0.299	32.5
Cohort 2
+	−	+	−	Agreement in BLI	0.466
Cohort 3
+	+	−	−	Agreement in blood vessel invasion	0.502	0.419 to 0.584	73.8
+	+	−	−	Agreement in lymphatic vessel invasion	0.153	0.071 to 0.236	33.8
Cohort 4
+	+	+	−	Agreement in BLI	0.622
Cohort 5
+	+	−	+	Agreement in blood vessel invasion	0.547	0.464 to 0.630	42.5
+	+	−	+	Agreement in lymphatic vessel invasion	0.492	0.409 to 0.575	26.9
Cohort 6
+	+	−	+	Agreement in blood vessel invasion	0.617	0.534 to 0.700	75.6
+	+	−	+	Agreement in lymphatic vessel invasion	0.618	0.534 to 0.700	31.9