TableĀ 1

Comparison of macroscopic, microscopic and ultrastructural features for oncocytoma and chromophobe renal cell carcinoma

FeaturesOncocytomaChromophobe RCC
MacroscopicWell circumscribed, tan or mahogany brown, sometimes with a central stellate scar30Usually circumscribed, homogenous, light brown, beige, yellow or tan colour.46
Cells arranged in a nested or organoid pattern, but tubular, trabecular or solid structure can also be seen.54
Granular eosinophilic cytoplasm
Round, uniform nuclei55
Variants: classic, eosinophilic and mixed.
Cells arranged in sheets, with distinct or accentuated cell borders.56
Granular eosinophilic (eosinophilic variant) or pale, reticular and almost transparent appearance (classic).57
Presence of perinuclear halos, wrinkled nuclei.57
UltrastructuralAbundant mitochondria with lamellar or focally stacked cristae. Absent or sparse vesicles.55Scant mitochondria with tubule-vesicular cristae. Abundant microvesicles between mitochondria.46