Comparison of macroscopic, microscopic and ultrastructural features for oncocytoma and chromophobe renal cell carcinoma
| Features | Oncocytoma | Chromophobe RCC |
|---|---|---|
| Macroscopic | Well circumscribed, tan or mahogany brown, sometimes with a central stellate scar30 | Usually circumscribed, homogenous, light brown, beige, yellow or tan colour.46 |
| Microscopic Cytoplasm Nuclei | Cells arranged in a nested or organoid pattern, but tubular, trabecular or solid structure can also be seen.54 Granular eosinophilic cytoplasm Round, uniform nuclei55 | Variants: classic, eosinophilic and mixed. Cells arranged in sheets, with distinct or accentuated cell borders.56 Granular eosinophilic (eosinophilic variant) or pale, reticular and almost transparent appearance (classic).57 Presence of perinuclear halos, wrinkled nuclei.57 |
| Ultrastructural | Abundant mitochondria with lamellar or focally stacked cristae. Absent or sparse vesicles.55 | Scant mitochondria with tubule-vesicular cristae. Abundant microvesicles between mitochondria.46 |