Table 1

Comparison of clinicopathological features between uVIN and dVIN

PrevalenceMore commonLess common
AgeYoung women (40–49 years)Postmenopausal women (66–69 years)
DistributionMultifocalUsually unifocal
Risk factorsHPV infection, immunosuppressionChronic skin inflammatory conditions (LS, lichen simplex chronicus, squamous cell hyperplasia)
Morphology▸ Nuclear atypia (high nuclear/cytoplasmic ratios, nuclear enlargement, hyperchromasia)
▸ Decreased cellular maturation
▸ Increased mitotic activity above basal layer
▸ Basal cell nuclear atypia
▸ Atypical mitosis in basal layer
▸ High maturation of superficial squamous cells
▸ Dyskeratosis, prominent nucleoli, elongation and anastomosis of rete ridges
▸ Prominent intercellular bridges
Type of SCCBasaloid/warty SCCKeratinizing SCC
Frequency of progression to invasive cancer5.7%33%
Immunohistochemistryp16+ (diffuse, band-like), p53−p53+(85%), p16− or focally +
  • dVIN, differentiated or simplex-type vulvar intraepithelial neoplasia; HPV, human papilloma virus; LS, lichen sclerosus; SCC, squamous cell carcinoma; uVIN, usual vulvar intraepithelial neoplasia.