TableĀ 2

Clinical performance of assays according to detection of high grade cytology (defined as moderate dyskaryosis or worse)

Sensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV (95% CI)Proportional Agreement* (95% CI)
HC2 at c/o 185 (68 to 95)79 (76 to 82)12 (8 to 17)99 (99 to 100)79 (77 to 82)
HC2 at c/o 279 (61 to 91)82 (80 to 85)13 (9 to 18)99 (98 to 100)82 (80 to 84)
Cervista79 (61 to 91)75 (72 to 77)9 (6 to 14)99 (98 to 100)75 (72 to 78)
AHPV85 (68 to 95)84 (82 to 87)15 (10 to 21)99 (99 to 100)84 (82 to 87)
rtHPV85 (68 to 95)78 (75 to 80)11 (8 to 16)99 (98 to 100)78 (75 to 81)
COBAS85 (68 to 95)75 (72 to 78)10 (7 to 14)99 (98 to 100)75 (73 to 78)
  • *At a threshold of moderate dyskaryosis or worse.

  • AHPV, aptima HPV test; c/o, cut off; HC2, hybrid capture 2 test; NPV, negative predictive value; PPV, positive predictive value; rtHPV, real time HPV test.