Reproducibility of some histological features
| Feature | Reproducibility | IOV%112533 | κ1162636869 |
|---|---|---|---|
| Architecture | |||
| Normal crypt architecture | Acceptable | – | >0.4 |
| Crypt distortion | Variable | 4–25 | 0.4–0.77 |
| Villous/irregular mucosal surface | Variable | 4–19 | 0.37–<0.4 |
| Crypt atrophy | Variable | 6–29 | 0.27–0.67 |
| Crypt branching | Variable | 26 | <0.4–0.47 |
| Crypt dilatation | Poor | 33 | 0.31 |
| Epithelium | |||
| Severe mucin depletion | Acceptable | – | >0.4 |
| Mucin depletion | Variable | 21 | >0.4–0.57 |
| Paneth cell metaplasia | Variable | 13 | 0.36–0.75 |
| Chronic inflammation | |||
| Basal plasmacytosis | Acceptable/good | – | 0.53–0.84 |
| Focal vs diffuse chronic inflammation | Acceptable/good | – | 0.54–0.87 |
| Normal lamina proprial cellularity | Acceptable | 17 | >0.4 |
| Basal lymphoid aggregates | Acceptable | 10–16 | 0.52 |
| Submucosal inflammation | Acceptable | 14 | 0.44–0.63 |
| Lamina proprial lymphocytes/plasma cells | Variable | 23–33 | 0.08–0.68 |
| Eosinophils | Variable | 23 | 0.32–0.51 |
| Histiocytes | Variable/poor | 46 | 0.07–0.6 |
| Granulomas/giant cells | |||
| Granuloma/epithelioid granuloma | Good | 4–6 | >0.4–1 |
| Giant cells (NOS/Langhans/isolated/basal) | Acceptable/good | 3–8 | 0.45–0.85 |
| Acute/active inflammation | |||
| Crypt neutrophils/crypt abscess/cryptitis | Acceptable | 18 | >0.4–0.66 |
| Ulceration/surface erosion | Variable | 15 | <0.4–0.56 |
| Lamina proprial neutrophils | Variable | 21 | >0.4–0.57 |
Reproducibility is arbitrarily classified as acceptable if κ is >0.4 and IOV <20%.
IOV, interobserver variability; NOS, not otherwise specified.