Lymph node revealing solution | Manual dissection | Fat clearance | Statistically significant difference? | ||
---|---|---|---|---|---|
No. cases | Mean no. lymph nodes | No. cases | Mean no. lymph nodes/(+) additional nodes | ||
Acetone*25 | 34 80 | 15.4 6.9 | 34 80 | +5.7 +4.4 | – |
Acetone/IPA/oil26 | – | – | 864 | 27.0 | – |
Acetone/xylene22 | 75 | 2.7 | 75 | +7.5 | – |
Acetone/alcohol/xylene18 | 22 | 4.7 | 10 | 30.9 | Yes (p<0.0001) |
Acetone/alcohol/xylene27 | 15 | 20.9 | 15 | +68.6 | – |
Acetone/alcohol/xylene28 | – | – | 311 | 74.3 | – |
Alcohol23 | 48 | 19.4 | 48 | +23.6 | No (p=0.177) |
Alcohol†29 | 82 | 9.6 5.2 | 155 | 27.6 20.4 | Yes (p<0.001) Yes (p<0.001) |
Alcohol33 | – | – | 27 | 34 | – |
Alcohol‡19 | 37 | 18.1/21.2 | 140/182 | 76.4/73.7 | – |
Alcohol/xylene31 | 41 | 21 | 43 | −9/−4 | – |
Alcohol/xylene30 | 10 | 18.7 | 10 | −2.3 | No (p=0.57) |
Alcohol/xylene32 | 103 | 6.2 | 103 | +12.4 | – |
Alcohol/xylene§21 | 221 50 | 10.5 13.1 | 51 | 23.1 | Yes (p<0.001) |
Alcohol/xylene17 | 41 | 7.3 | 41 | +47.6 | – |
Alcohol/xylene20 | – | – | 48 | 50.2 | – |
GEWF37 | 40 | 18.30 | 45 | 19.96 | No (p=0.53) |
GEWF¶42 | 30 12 | 5.1 6.25+1.6 | 30 12 | +1.73 +1.2 | Yes (p<0.01) Yes (p<0.01) |
GEWF36 | 32 | 6.8 | 35 | 10.2 | Yes (p=0.002) |
GEWF41 | 30 | 2.94 | 30 | +8.6 | – |
GEWF40 | 35 | 6.26 | 35 | +13.0 | – |
GEWF‡38 | 59 | 10 9 | 61 | 17 16 | Yes (p<0.001) |
GEWF39 | 117 | 5.0 | 125 | 13.0 | Yes (p<0.001) |
GEWF35 | 34 | 5.9 | 59 | 14.7 | Yes (p=0.05) |
GEWF3 | 423 | 11.4 | 423 | +6.0 | – |
GEWF**43 | 76 | – | 62 | – | – |
GEWF44 | 8 | 7.6 | 8 | +4.7 | Yes (p<0.5) |
*Two study groups.
†Non-neoadjuvant/neoadjuvant.
‡Colonic/rectal.
§Multiple sites with lymph node clearance performed at the main site only.
¶Two study groups, multiple dissections and multiple sites of tumour.
**Comparison of cases from different years; also includes assessment of improved surgical practice.
GEWF, glacial acetic acid, ethanol, water and formalin.