Table 1

Function and prognostic role of CAF-related proteins

ProteinRole in tumour biologyDisease and references
FAPTumour cell growth, proliferation, ECM remodelling, metastasis formation and angiogenesis37DCIS, NSCLC, CRC38–40
PDGF/PDGFRsAngiogenesis, regulation of interstitial fluid pressure in tumours41Pancreas and breast carcinoma, NSCLC42–44
TN-CHypoxia-driven angiogenesis, proliferation, migration, escape from immune surveillance8CRC, breast cancer, melanoma 8
PDPNCancer cell invasion45LACC, CRC (good prognosis) breast cancer, oesophagus adenocarcinoma45–48
SPARCCell migration, proliferation, matrix cell adhesion and tissue remodelling49Pancreatic cancer, NSCLC49 50
MetReceptor of HGF, it plays a role in the tumour cell invasion and CAF proliferation51LACC52
TGF-β/TGFβRsTumour growth, proliferation, invasiveness, angiogenesis, immunesuppression.53 54CRC and breast cancer55 56
  • CAF, cancer associated fibroblast; CRC, colorectal carcinoma; DCIS, ductal carcinoma in situ; ECM, extracellular matrix; FAP, fibroblast activation protein; HGF, hepatocyte growth factor; LACC, lung adenocarcinoma; NSCLC, non-small cell lung cancer; PDGF, platelet-derived growth factor; PDGFR, platelet-derived growth factor receptor; PDPN, podoplanin; TGF-β, transforming growth factor-β; TN-C, tenascin-C; SPARC, secreted protein acidic and rich in cysteine; Met, hepatocyte-derived growth factor receptor.