Table 4

Multivariable survival analysis by Cox proportional hazards regression model: Väyrynen–Mäkinen criteria for CLR variable

VariablesCase NoHR (95% CI)p Value
Väyrynen–Mäkinen criteria-based CLR status
 Low density (<0.38 LAs/mm)74Reference
 High density (≥0.38 LAs/mm)1380.5 (0.28 to 0.89)0.017
AJCC/UICC TNM stage
 Stage I/II138Reference
 Stage III/IV743.68 (1.98 to 6.82)<0.001
WHO tumour grade
 G1/G2170Reference
 G3421.63 (0.89 to 3)0.117
Age (years)
 <58101Reference
 ≥581111.51 (0.78 to 2.92)0.227
CIMP status
 CIMP-L/0158Reference
 CIMP-H541.34 (0.69 to 2.61)0.39
  • CLR, Crohn-like lymphoid reaction; CIMP, CpG island methylator phenotype; CIMP-H, CIMP-high; CIMP-L/0, CIMP-low or CIMP-negative; LA, lymphoid aggregate; AJCC/UICC, American Joint Committee on Cancer/Union for International Cancer Control.