Multivariable survival analysis by Cox proportional hazards regression model: Väyrynen–Mäkinen criteria for CLR variable
| Variables | Case No | HR (95% CI) | p Value |
|---|---|---|---|
| Väyrynen–Mäkinen criteria-based CLR status | |||
| Low density (<0.38 LAs/mm) | 74 | Reference | |
| High density (≥0.38 LAs/mm) | 138 | 0.5 (0.28 to 0.89) | 0.017 |
| AJCC/UICC TNM stage | |||
| Stage I/II | 138 | Reference | |
| Stage III/IV | 74 | 3.68 (1.98 to 6.82) | <0.001 |
| WHO tumour grade | |||
| G1/G2 | 170 | Reference | |
| G3 | 42 | 1.63 (0.89 to 3) | 0.117 |
| Age (years) | |||
| <58 | 101 | Reference | |
| ≥58 | 111 | 1.51 (0.78 to 2.92) | 0.227 |
| CIMP status | |||
| CIMP-L/0 | 158 | Reference | |
| CIMP-H | 54 | 1.34 (0.69 to 2.61) | 0.39 |
CLR, Crohn-like lymphoid reaction; CIMP, CpG island methylator phenotype; CIMP-H, CIMP-high; CIMP-L/0, CIMP-low or CIMP-negative; LA, lymphoid aggregate; AJCC/UICC, American Joint Committee on Cancer/Union for International Cancer Control.