Genomic alterations (GAs) identified in 29 cases of adrenocortical carcinoma (ACC)
| Case | Median coverage depth | Total GAs | Actionable GAs | GAs present in each ACC |
|---|---|---|---|---|
| 1 | 358 | 2 | 0 | RB1 (S414fs*10); TP53 (C124fs*25) |
| 2 | 491 | 3 | 2 | CCND2 (amp); CDK4 (amp); PDRM1 (R921*) |
| 3 | 611 | 3 | 1 | EP300 (P925T) |
| 4 | 699 | 0 | 0 | |
| 5 | 1122 | 1 | 0 | TP53 (R282W) |
| 6 | 666 | 4 | 1 | DNMT3A (splice); LRP1B (splice); RB1 (loss); TP53 (C176F) |
| 7 | 736 | 1 | 1 | PDGFRB (amp) |
| 8 | 657 | 0 | 0 | |
| 9 | 861 | 0 | 0 | |
| 10 | 1259 | 1 | 1 | CDKN2A (loss) |
| 11 | 921 | 1 | 0 | CTNNB1 (E15*) |
| 12 | 479 | 1 | 1 | NF1 (F1708fs*2) |
| 13 | 1108 | 4 | 3 | CDK4 (amp); CUL4A (V275M); MDM2 (amp); TP53 (S241Y) |
| 14 | 1138 | 0 | 0 | |
| 15 | 671 | 4 | 1 | DAXX (A47fs*92); EGFR (P848 L); KDM5C (V833fs*21);TP53 (F134C) |
| 16 | 1035 | 1 | 1 | ATM (R337H) |
| 17 | 710 | 6 | 3 | EPHB1 (P167 L); ERBB4 (amp); KEAP1 (V369 L); NRAS (G13 V); STK11 (D194Y); TP53 (C135W) |
| 18 | 856 | 3 | 3 | ATM (R3008C); BAP1 (E54*); NF1 (C509fs*1) |
| 19 | 571 | 2 | 0 | CTNNB1 (S45P); MEN1 (V58fs*60) |
| 20 | 658 | 0 | 0 | |
| 21 | 633 | 12 | 5 | APC (R1171H); ATRX (T1582fs*24); GATA1 (T402fs*14+); MEN1 (R521fs*43); NF1 (E2029*, G849fs*29); PIK3CA (H1047R); PTCH1 (S1203fs*52); PTEN (N323fs*2); SPRN (P3317fs*83); TP53 (R273H) |
| 22 | 552 | 7 | 3 | CCND1 (amp); CDKN2A (loss); CTNNB1 (S37C); ETV6 (truncation); FGF23 (amp); KRAS (amp); MEN1 (F43fs*74) |
| 23 | 558 | 7 | 3 | AURKB (R123H); CDKN2A (loss); FGF3 (H122N); MCL1 (amp); MYC (amp); TP53 (V173 L & K132N) |
| 24 | 722 | 1 | 0 | SETD2 (T1652fs*14) |
| 25 | 862 | 0 | 0 | |
| 26 | 486 | 6 | 1 | APC (S1465fs*3); ATM (R189 K); DAXX (H620fs*37); KDM5C (L1305fs*5); MSH2 (splice site 1760-2A>G); TP53 (R213*) |
| 27 | 660 | 0 | 0 | |
| 28 | 691 | 3 | 3 | AKT2 (amp); CCNE1 (amp); DNMT3A (loss) |
| 29 | 529 | 3 | 1 | CDKN2A (I49 T); LRP1B (loss); TP53 (M237I) |