Parameter estimates OR (95% CI) | ||||
---|---|---|---|---|
Dysplasia | Oral squamous cell carcinoma | |||
N= | Mild (n=37) | Moderate/severe (n=34) | Well differentiated (n=86) | Poorly differentiated (n=27) |
Variables in the model | ||||
hMLH1 | 0.92** (0.88 to 0.97) | 0.97 (0.92 to 1.03) | 0.92* (0.88 to 0.96) | 0.92** (0.85 to 1.00) |
hPMS2 | 0.94** (0.91 to 0.98) | 0.98 (0.94 to 1.03) | 0.94* (0.90 to 0.97) | 0.89* (0.84 to 0.95) |
hMSH2 | 0.96 (0.92 to 1.00) | 0.97 (0.93 to 1.01) | 0.93** (0.89 to 0.97) | 0.86* (0.81 to 0.91) |
Control variables | ||||
Age | 1.02 (0.98 to 1.05) | 1.04** (1.00 to 1.07) | 1.06** (1.02 to 1.09) | 1.07** (1.02 to 1.13) |
The reference group is normal; *p<0.0001, **p<0.05. The general formula by which the model was designed is as follows: in which p=probability, Dx=Diagnosis of sample (mild dysplasia, moderate/severe dysplasia, well-differentiated OSCC and poorly differentiated OSCC), b=interface, β=coefficient for each independent variable, x=independent variable and i=score for which model is calculated. Following equations were used for data shown in the table:
OSCC, oral squamous cell carcinoma.