Multivariable survival analysis by Cox proportional hazards regression model: Ueno criteria for CLR variable
| Variables | Case No | HR (95% CI) | p Value |
|---|---|---|---|
| Ueno criteria-based CLR status | |||
| Inactive (largest LA size <1 mm) | 126 | Reference | |
| Active (largest LA size ≥1 mm) | 86 | 0.47 (0.24 to 0.9) | 0.024 |
| AJCC/UICC TNM stage | |||
| Stage I/II | 138 | Reference | |
| Stage III/IV | 74 | 3.61 (1.96 to 6.67) | <0.001 |
| WHO tumour grade | |||
| G1/G2 | 170 | Reference | |
| G3 | 42 | 1.86 (1.01 to 3.41) | 0.046 |
| Age (years) | |||
| <58 | 101 | Reference | |
| ≥58 | 111 | 1.39 (0.72 to 2.7) | 0.332 |
| CIMP status | |||
| CIMP-L/0 | 158 | Reference | |
| CIMP-H | 54 | 1.38 (0.71 to 2.7) | 0.347 |
CLR, Crohn-like lymphoid reaction; CIMP, CpG island methylator phenotype; CIMP-H, CIMP-high; CIMP-L/0, CIMP-low or CIMP-negative; LA, lymphoid aggregate; AJCC/UICC, American Joint Committee on Cancer/Union for International Cancer Control.