Table 3

Multivariable survival analysis by Cox proportional hazards regression model: Ueno criteria for CLR variable

VariablesCase NoHR (95% CI)p Value
Ueno criteria-based CLR status
 Inactive (largest LA size <1 mm)126Reference
 Active (largest LA size ≥1 mm)860.47 (0.24 to 0.9)0.024
 Stage I/II138Reference
 Stage III/IV743.61 (1.96 to 6.67)<0.001
WHO tumour grade
 G3421.86 (1.01 to 3.41)0.046
Age (years)
 ≥581111.39 (0.72 to 2.7)0.332
CIMP status
 CIMP-H541.38 (0.71 to 2.7)0.347
  • CLR, Crohn-like lymphoid reaction; CIMP, CpG island methylator phenotype; CIMP-H, CIMP-high; CIMP-L/0, CIMP-low or CIMP-negative; LA, lymphoid aggregate; AJCC/UICC, American Joint Committee on Cancer/Union for International Cancer Control.