Table 4

Grouping of antibodies into positive and negative staining with separation of categories as shown, excluding cases of non-infectious deaths

AntibodyHistological infectionNo histological infectionSensitivitySpecificity
CRP (liver) diffuse staining
 Positive202100% (83.2% to 100%)96.7% (88.5% to 99.6%)
 Negative058
CRP (heart) any staining
 Positive18190% (68.3% to 98.8%)98.3% (91.1% to 100%)
 Negative259
Interleukin 6 (liver) any staining
 Positive91545% (23.1% to 68.5%)75% (62.1% to 85.3%)
 Negative1145
ICAM-1 (liver) any staining
 Positive12460% (36.1% to 80.9%)93.3% (83.8% to 98.2%)
 Negative856
ICAM-1 (heart) diffuse staining
 Positive10050% (27.2% to 72.8%)100% (94% to 100%)
 Negative1060
  • Sensitive and specificity for each antibody is demonstrated, along with 95% CIs in parentheses.

  • CRP, c-reactive protein.