Table 5

Summary of modified-Folpe criteria

BenignLess than or one worrisome feature (including invasive edge, size ≥5 to <10 cm, mitoses two to three per 50 HPF, lymphovascular invasion)
Uncertain malignant potentialOne worrisome feature that includes isolated marked atypia, size ≥10 cm or mitotic count greater than or four per 50 HPF
MalignantAny necrosis or two worrisome features
  • Caution should be exercised when evaluating tumours exhibiting LVI as the sole worrisome feature, as there are very limited data on outcomes in patients with such tumours.

  • HPF, high power field.