Expression of proteins in relation to WHO grading and PDPN/mutIDH1 expression
| PDPN (n=354) | mutIDH1 (n=348) | tcCXCR7 (n=320) | vasCXCR7 (n=320) | tcSDF1a (n=311) | vasSDF1a (n=311) | Ki67 high (n=307) | |
|---|---|---|---|---|---|---|---|
| Evaluation criteria for the semiquantitative analysis | ≥80% glioma cells show distinct staining | ≥50% glioma cells show distinct staining | At least one positive tumour cell | At least one positive tumour vessel | At least one positive tumour cell | At least one positive tumour vessel | Ki67 index ≥5% |
| All cases | 129 (36.4%) | 83 (23.9%) | 37 (11.6%) | 186 (58.1%) | 111 (35.7%) | 194 (62.4%) | 230 (74.9%) |
| PDPN+ | 125 (100%) | – | 19 (17.6%) | 84 (77.8%) | 51 (48.1%) | 66 (62.3%) | 90 (90.9%) |
| mutIDH1 | 2 (2.4%) | 83 (100%) | 4 (5.2%) | 20 (26.0%) | 13 (17.6%) | 47 (63.5%) | 34 (44.7%) |
| All others | – | – | 13 (10.0%) | 80 (61.5%) | 44 (34.6%) | 79 (62.2%) | 101 (79.5%) |
| WHO grade IV | 120 (48%) | 19 (7.8%) | 33 (14.7%) | 164 (73.2%) | 95 (42.8%) | 135 (60.8%) | 194 (90.7%) |
| WHO grade III | 6 (18.8%) | 13 (41.9%) | 2 (6.5%) | 13 (41.9%) | 12 (40.0%) | 23 (76.7%) | 22 (75.9%) |
| WHO grade II | 3 (4.2%) | 51 (70.8%) | 2 (3.1%) | 9 (13.8%) | 4 (6.8%) | 36 (61%) | 14 (21.9%) |
Percentages are row percentages.
mutIDH1, mutant isocitrate dehydrogenase 1; PDPN, podoplanin.